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Vacancies in the School of Biochemistry and Immunology

 

Research Opportunities

Other Vacancies

 


 

POST-GRADUATE VACANCIES


 

POST-GRADUATE VACANCY

PhD Studentship in Immunology

A Postgraduate Fellowship is available from Sept 2014 to work on the regulation of pathogenic T cells in autoimmunity.

This post is funded by a 5-year SFI PI Award to Prof. Kingston Mills entitled ‘New immunotherapeutic approaches based on the Th1/Th17 axis and its regulation’. The overall aim of which is to understand the role of innate immune responses in directing T cell differentiation and the consequences of disrupting the balance between regulatory and effector (Th1) or pathogenic (Th17) T cells on the development of autoimmunity or in protection against pathogens or tumors, using models of humans diseases. The project includes studies on the development of vaccines and immunotherapeutics for autoimmune diseases. The PhD project will focus on the exploitation of pathogen-derived molecules in the development of immunotherapeutic approaches to control pathogenic Th1/Th17 cells in mouse models of colitis and multiple sclerosis.  

The Immune Regulation Research Group is located in School of Biochemistry and Immunology, The Trinity Biomedical Sciences Institute, Trinity College Dublin. Further details at: http://www.tcd.ie/Biochemistry/research/k_mills.php

The Fellowship will be for 3 years with registration for a PhD degree by research
Annual stipend of €18,000 + postgraduate student fees.

Candidates should have a strong academic track record and a proven interest in research and have or expect to achieve a II.1 or 1st class honours degree or MSc in a biological science, preferably with an element of immunology in the course.

Applications by email to include CV (please include exam grades to date), abstract of final year B.A.(Mod)/ B.Sc. project and the names and email addresses of 2 referees to Prof Kingston Mills; kingston.mills@tcd.ie by 30th April 2014.

 


 

POST-GRADUATE VACANCY

Post Title:

PhD studentship: Modulation of innate and adaptive immunity by particulate adjuvants for improved parenteral and mucosal vaccination

Post Status:

Research PhD. Fully funded for 4 years.

Department/Faculty:

School of Biochemistry and Immunology

Location:

Trinity Biomedical Sciences Institute

Reports to

Dr Ed Lavelle

Stipend:

€18,000 per annum

Closing Date:

5pm on Friday 30th May, 2014

The successful candidate will be expected to take up this position on September 1st 2014.

Post Summary

Objective: To conduct postgraduate research leading to a PhD as part of the Principal Investigator’s research programme on vaccine adjuvants.

 

Background to the Post

Vaccine research is undergoing a phase of expansion due to the need for new vaccines to combat existing, emerging, and drug resistant infections. While significant recent progress has been made in the identification of novel antigens from a number of pathogens, there is an urgent need for new adjuvants to induce protective immune responses; particularly for diseases where cell-mediated immunity is essential, such as tuberculosis, HIV infection and pneumococcal infection. However, it is essential that we understand the relationship between the nature of vaccine adjuvants and the immune responses induced. In this Science Foundation Ireland funded programme, we will determine the role of key regulatory cytokines (particularly IL-1 family cytokines) in mediating innate and adaptive immune responses to antigens formulated with the particulate adjuvants, poly (lactide-co-glycolide) (PLG) micro and nanoparticles and chitosan.  Based on these systems, we will exploit exciting preliminary data using immunostimulatory and targeting molecules to develop novel vaccine adjuvants.  

References:
Oleszycka, E. and Lavelle, E.C. (2014).  Current Opinion in Immunology. 28C, 1-5.
Mori, A., Oleszycka, E. et al (2012). The European Journal of Immunology.  42, 1-11.
Schijns,V.E.J.C and Lavelle, E.C (2011). Expert Reviews in Vaccines. 10, 4, 539-550.
Sharp, F et al (2009). Proceedings of the National Academy of Sciences of the U.S.A. 106, 3, 870-875.

 

Standard duties of the Post

  • Carrying out vaccination studies and assessment of antigen specific immunity.
  • Evaluation of adjuvant induced innate immunity and investigating the roles of key cytokines.
  • Writing research papers and reviews.
  • Presentation of data at lab meetings, school and institute seminars, site reviews and national and international meetings.

Funding Information

  • The posts are funded under an SFI Investigator Programme grant awarded to Ed Lavelle.

Qualifications

Applications are invited from outstanding candidates with a suitable qualification (BA(Mod), BSc, MSc) in Immunology, Biochemistry or a related subject

 

Application Procedure

Candidates should submit a cover letter together with a full curriculum vitae to include the names and contact details of at least 2 referees (email addresses if possible) to Dr Ed Lavelle, lavellee@tcd.ie

 

Further Information

School of Biochemistry and Immunology Summary

Information about Trinity College Dublin


 

POST-GRADUATE VACANCY

Post Title:

PhD studentship:  Crystallography of Membrane Trafficking Complexes

Post Status:

 

Research Group/Department/School:

School of Biochemistry and Immunology

Location:

Trinity Biomedical Sciences Institute

Reports to:

Principal Investigator

Salary:

18,000 euros

Closing Date and Time:

1 June 2014

Post Summary
One of the major themes in the lab is the mechanism by which intracellular bacteria subvert the host cell trafficking machinery to develop a replication niche in the cytosol.  The student project involves the crystallization of bacterial proteins in complex with their cellular targets, in particular human Rab and Arf small GTPases.  In addition, biophysical analyses of protein-protein interactions will be studied using fluorescence, surface plasmon resonance and calorimetry.

Standard duties and Responsibilities of the Post
The position is a research PhD, fully funded (tuition + stipend) for 3 years.  The student is expected to supplement the practical work with regular attendance at lab meetings, delivery of public lectures, and departmental seminars.

Funding Information

  • Science Foundation Ireland

Person Specification

 

Qualifications

  • BA/BSc graduate of Biochemistry or related field

Knowledge & Experience (Essential & Desirable)

  • The position is funded strictly for 3 years, therefore proficiency in at least two of molecular biology, protein purification or crystallographic methods is required for consideration of the application

Skills & Competencies

  • An ambitious, organized and highly motivated student is preferred for this post. The research is supported by collaborations with outstanding cell biologists, and there are frequent trips to synchrotron facilities.  Therefore, there is every opportunity to perform significant and world-class research at Trinity college Dublin.

Further Information for Candidates


URL Link to School

http://www.tcd.ie/Biochemistry/

URL Link to Research Group

http://www.tcd.ie/Biochemistry/research/a_khan/index.php

URL Link to Human Resources

https://jobs.tcd.ie/pls/corehrrecruit/erq_search_package.search_form?p_company=1&p_internal_external=E

 

 

Further Information

School of Biochemistry and Immunology Summary

Information about Trinity College Dublin


 

RESEARCH ASSISTANT VACANCY

Post Title:

Research Assistant

Post Status:

 

Research Group/ Department/School:

School of Biochemistry and Immunology

Location:

Trinity Biomedical Sciences Institute

Reports to:

Principal Investigator

Salary:

21,850 euro (gross)

Closing Date and Time:

1 May 2014

Post Summary
The position is in support of the structural biology group of Dr. Amir Khan.  The projects are diverse and involve the crystallization of bacterial/cellular protein complexes associated with membrane trafficking, as well as viral/cellular complexes that antagonize innate immunity.

Standard duties and responsibilities of the post
Duties in the lab include administrative support (primarily ordering of biochemicals), equipment maintenance, and support for the ongoing research.  Techniques employed in the lab include large-scale protein production in bacterial cultures, protein purification using FPLC systems, and protein crystallization.  Furthermore, a complete biophysics suite is available, including light scattering, calorimetry, surface plasmon resonance and stopped-flow fluorescence.

Funding Information

  • Science Foundation Ireland

Person Specification

Qualifications

  • BA/BSc graduate of Biochemistry or related field

Knowledge & Experience (Essential & Desirable)

  • experience in molecular biology, particularly in sub-cloning techniques, is essential
  • experience in protein purification using FPLC systems is highly desirable

Skills & Competencies

  • candidate must be organized, self-motivated and pro-active in a laboratory setting

Further Information for Candidates


URL Link to School

http://www.tcd.ie/Biochemistry/

URL Link to Research Group

http://www.tcd.ie/Biochemistry/research/a_khan/index.php

URL Link to Human Resources

https://jobs.tcd.ie/pls/corehrrecruit/erq_search_package.search_form?p_company=1&p_internal_external=E

 

 

Further Information

School of Biochemistry and Immunology Summary

Information about Trinity College Dublin



POST-DOCTORAL VACANCIES

 



Information for Prospective Post Graduate Students

Please feel free to contact a potential supervisor directly if you are interested in their area of research. For a full list of the research activities undertaken in the school please click on Research Activities.

Information for Prospective Graduate Students is available on the School's Postgraduate webpage

For a useful general site for post-graduate positions in Europe please click on http://www.findaphd.com/

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Contact: bbutler@tcd.ie.
Last updated: Apr 15 2014.