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POSTDOCTORAL VACANCIES


Post-doctoral Research Fellow Positions in Immunometabolism (2)

The Finlay Lab at Trinity College Dublin (TCD) is seeking applicants for 2x European Research Council (ERC) funded Post-Doctoral Research Fellow positions. The Immunometabolism research group, led by Dr. David Finlay, is focused on investigating how nutrients and cellular metabolism impact upon the fate and function of immune cells, including Natural Killer cells and Dendritic cells (www.tcd.ie/Biochemistry/research/d_finlay.php).

The successful applicants will join a dynamic research team aimed at generating novel and progressive insights into nutrient regulated immune responses. The team uses an integrative approach combining experimental techniques such as metabolomics, metabolic analyses, mouse transgenics, confocal imaging and in vivo mouse models. We are looking for highly-motived candidates with strong backgrounds in immunology. For the first position, experience in confocal imaging is preferable. For the other position, experience with in vivo mouse models and flow cytometry is desirable. The Post-Doctoral researchers will actively support PhD students and undergraduate students in the lab, present at national and international meetings and publish in leading international journals.

Scientific background: Our recent research demonstrates that nutrients are dynamically controlled and are not equally available to all immune cells. The Finlay group has shown that nutrient deprived DC have altered signalling, increased pro-inflammatory functions and induce enhanced T cell responses. However, understanding whether DC can become nutrient deprived in vivo is a major challenge as the tools to investigate nutrient dynamics within complex microenvironments have not yet been developed. Dr Finlay’s ERC research programme will generate innovative new technologies to measure the local distribution of nutrients allowing them to be visualised and quantified. Nutrient deprivation of antigen presenting DC will then be investigated in response to various stimuli within the inflammatory lymph nodes and correlated to CD8 T cell responses. State-of-the-art transgenic mice will be generated to specifically knock-down nutrient transporters in DC to prove that the availability of these nutrients to antigen presenting DC is a key mechanism for controlling CD8 T cells responses. This would be a paradigm shifting discovery that would open new horizons for the study of nutrient-regulated immune responses.

TCD is Ireland’s top ranked University and a member of the League of European Research Universities (LERU). The Finlay Lab is funded by a European Research Council (ERC) Consolidator Grant (2018 – 2023) and a Science Foundation Ireland (SFI) Career Development Award and is located in the state of the art Trinity Biomedical Sciences Institute (TBSI), which has excellent facilities for mouse transgenics, microscopy and metabolic analyses.

Requirements: A PhD in Immunology, cell biology, or related discipline with proven publication record and excellent communication skills.

Closing Date for applications: February 9th 2018 or until a suitable candidate is identified.

Please submit a covering letter and CV (include the names and contact details of 2 referees) to: finlayd@tcd.ie. Starting date is flexible but aimed at April 2018. Informal discussions prior to applications are very welcome.


Post Doctoral Research Fellow Investigating Host-Pathogen Interactions


Position description:
Applications are invited for an ambitious postdoctoral research position in cellular immunology funded by the Wellcome Trust. The postdoctoral fellow will lead an exciting new project investigating the impact of the bacterium Staphylococcus aureus on the immune system during commensal colonisation. This project will employ a range of immunological techniques to investigate immune memory associated with S. aureus colonisation in the healthy population.

The successful candidate will join the Host-Pathogen Interactions group led by Dr Rachel McLoughlin at the School of Biochemistry and Immunology at Trinity College Dublin (http://www.tcd.ie/Biochemistry/research/r_mcloughlin.php) The School of Biochemistry and Immunology provides a dynamic and stimulating environment and the candidate will have the opportunity to interact with world-class immunology researchers working in areas such as innate immunity, vaccine development and immuometabolism.

We are looking for a highly motived candidate with a strong background in immunology, ideally in the context of infection. Candidates should also have experience with in vivo models, flow cytometery and working with primary human cells. The postdoc will actively support PhD students and undergraduate students in the lab, present at national and international meetings and publish in leading international journals.

Scientific Background: The WHO highlights the epidemic of antibiotic resistance in Staphylococcus aureus (MRSA) as a particular threat to society, strongly advocating for the development of alternatives to antibiotics. Over the past 15 years significant efforts have been made to develop an anti-S. aureus vaccine but to-date none have been successful. What is it about S. aureus that makes it so difficult to vaccinate against? The primary goal in the lab is to address this question. Specifically, this program will investigate the influence of S. aureus colonisation on the host immune system. In addition to causing severe invasive disease, S. aureus lives innocuously in the nasal passages of the majority of the population. However, we understand very little about how exposure to S. aureus in this context affects our immune system or how this exposure might influence our ability to respond to a vaccine against this organism.

Requirements: A PhD in Immunology or cell biology with proven publication record and excellent communication skills.

Closing Date for applications: Jan 31st 2018 or until a suitable candidate is identified

Please submit a covering letter and CV (include the names and contact details of 2 referees) to: rachel.mcloughlin@tcd.ie
Trinity College Dublin is an equal opportunities employer.


Last updated 22 January 2018 bbutler@tcd.ie (Email).