Publications

INFLAMMATION RESEARCH GROUP

Palsson- McDermott E, Doyle S, McGettrick A, Hardy M, Husebye H, Banahan K, Gong M, Golenbock D, Espevik T and O'Neill LA (2009) TAG: a GOLD domain-containing splice variant of TRAM that negatively regulates the MyD88-independent pathway in TLR4 signaling. Nature Immunology 10, 579-586

Corr SC and O'Neill LA (2009) Listeria monocytogenes infection in the face of innate immunity. Cellular Microbiology (in press)

O'Neill LA, Bryant CE and Doyle SL (2009) Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacological Reviews 61(2):177-97

Ferwerda B, Alonso S, Banahan K, McCall MB, Giamarellos-Bourboulis EJ, Ramakers BP, Mouktaroudi M, Fain PR, Izagirre N, Syafruddin D, Cristea T, Mockenhaupt FP, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Sundaresan S, Bedu-Addo G, van Crevel R, Hamann L, Oh DY, Schumann RR, Joosten LA, de la Rúa C, Sauerwein R, Drenth JP, Kullberg BJ, van der Ven AJ, Hill AV, Pickkers P, van der Meer JW, O'Neill LA, Netea MG. (2009) Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A. 106(25):10272-7.

Carpenter S, O'Neill LA (2009) Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. Biochem J. 422(1):1-10.

Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA. (2009) TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain. J Immunol. 183(6):3989-95.

Kenny EF, Talbot S, Gong M, Golenbock DT, Bryant CE, O'Neill LA MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3. (2009) J Immunol. 183(6):3642-51.

Becker CE, Creagh EM, O'Neill LA. Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion. (2009) J Biol Chem. 284(50):34531-7.

McCormack WJ, Parker AE, O'Neill LA. Toll-like receptors and NOD-like receptors in rheumatic diseases. (2009) Arthritis Res Ther. 11(5):243.

O'Neill LA (2009) A feed-forward loop involving hyaluronic acid and toll-like receptor-4 as a treatment for colitis? Gastroenterology. 137(6):1889-91.

O'Neill LA (2009) Boosting the brain's ability to block inflammation via microRNA-132. Immunity 31(6):854-5

Zhang X, Shephard F, Kim HB, Palmer IR, McHarg S, Fowler GJ, O'Neill LA, Kiss-Toth E, Qwarnstrom EE. (2010) TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB. J Biol Chem 285(10):7222-32.

Lavelle EC, Murphy C, O'Neill LA, Creagh EM. (2010) The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal Immunol. 3(1):17-28.

Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q, Johnson DS, Chen Y, O'Neill LA. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. (2010) Nat Immunol. 11(2):141-7.

Arslan F, Smeets MB, O'Neill LA, Keogh B, McGuirk P, Timmers L, Tersteeg C, Hoefer IE, Doevendans PA, Pasterkamp G, de Kleijn DP. (2010 ) Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. Circulation. 121(1):80-90.

McGettrick AF, O'Neill LA (2010) Localisation and trafficking of Toll-like receptors: an important mode of regulation. Curr Opin Immunol 22(1):20-7

O'Neill LA and Bowie AG (2010) Innate immune sensing of nucleic acids. Current Biology 20(7):R328-33

Hennessy E, Parker A and O'Neill LAJ (2010) Targeting Toll-like receptors: emerging therapeutics? Nature Reviews Drug Discovery 9(4):293-307

Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, Morrice N, O'Neill LA. (2010) IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). J Biol Chem 285(24):18276-82

McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA (2010 ) IL-10 inhibits miR-155 induction by toll-like receptors. J Biol Chem 285(27):20492-8

Madden SF, Carpenter SB, Jeffery IB, Björkbacka H, Fitzgerald KA, O'Neill LA, Higgins DG. (2010) Detecting microRNA activity from gene expression data. BMC Bioinformatics. 11:257-267.

McGettrick AF, O'Neill LA. (2010) Regulators of TLR4 Signaling by Endotoxins. Subcell Biochem 53:153-71

Plantinga TS, Hamza OJ, Willment JA, Ferwerda B, van de Geer NM, Verweij PE, Matee MI, Banahan K, O'Neill LA, Kullberg BJ, Brown GD, van der Ven AJ, Netea MG (2010) Genetic Variation of Innate Immune Genes in HIV-Infected African Patients With or Without Oropharyngeal Candidiasis. J Acquir Immune Defic Syndr. 55, 87-94

Coll RC, O'Neill LA. (2010) New Insights into the Regulation of Signalling by Toll-Like Receptors and Nod-Like Receptors. May 27. [Epub ahead of print]

O'Neill LA (2010) Stopping sepsis by targeting sphingosine kinase 1. Science Translational Medicine 16;2(36):36ps29

Masters SL, Dunne AD, Subramanian SL, Hull RL, Tannahill G, Sharp F, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll R, Mok K, Newsholme P, Nunez G, Yodoi J, Kahn S, Lavelle EC and O'Neill LAJ (2010) Activation of the Nlrp3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in Type 2 diabetes. Nature Immunol 11, 579-586

Dinarello, C, Arend W, Sims J, Smith D, Blumberg H, O'Neill L et al (2010) IL-1 family nomenclature. Nature Immunology 11, 973