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PublicationsNEUROCHEMISTRY, ENZYMOLOGY AND SYSTEMS BIOLOGY GROUPProf Keith TiptonNeurochemistry, enzymology & biochemical pharmacology Conversion of taurine into N-chlorotaurine (taurine chloramine) and sulphoacetaldehyde in response to oxidative stress. C. Cunningham, K.F. Tipton and H.B.F. Dixon Biochem. J. 330 933-937 (1998). Purification and characterization of membrane-bound semicarbazide-sensitive amine oxidase (SSAO) from bovine lung. J.M. Lizcano, K.F. Tipton and M. Unzeta. Biochem. J. 331, 69-78 (1998) The oxidation of dopamine and epinine by the two forms of monoamine oxidase from rat liver. M. Strolin Benedetti, M. Sanson, G. Bona, M. Gallina, S. Persiani and K.F. Tipton. J. Neural Transm. (Suppl.) 52, 233-238 (1998). Studies on the time-dependent activation of microsomal semicarbazide-sensitive amine. J.M. Lizcano, A. Fernandez de Ariba, K.F. Tipton and M. Unzeta. J. Neural Transm. (Suppl.) 52, 251-257 (1998). Studies on the behaviour of semicarbazide-sensitive amine oxidases in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine. D. Fitzgerald, K.F. Tipton and G.A. Lyles. J. Neural Transm. (Suppl.) 52, 259-264 (1998). Analysis of salsolinols, endogenous neurotoxins, in human materials. M. Naoi, W. Maruyama, K. Matsubara, K.F. Tipton. M. Strolin Benedetti and H. Parvez. In: Neurochemical markers of degenerative nervous diseases and drug addiction. (Edited by G.A. Qureshi, H. Parvez, P. Caudy and S. Parvez). VSP, The Netherlands. Progress in HPLC-HPCE 7, 423-460 (1998). Antagonism by taurine of the ruthenium red-induced and 6-hydroxydopamine plus 1-methyl-4-phenylpyridinium-induced Ca2+ release from rat liver mitochondria. M. Palmi, G. Youmbi, F. Fusi, M. Frosini, G.P. Sgaragli, L. Della Corte and K.F. Tipton. In: Taurine 3: cellular and regulatory mechanisms. (Edited by S. Schaffer, J.B. Lombardini and R.J. Huxtable), Plenum Press, New York. Adv.Exp. Biol. Med. 442, 91-98 (1998). Mechanism of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine and its prevention by desferrioxamine. Y. Glinka, K.F. Tipton and M.B.H. Youdim. Eur. J. Pharmacol. 351,121-129 (1998). Platelet MAO activity in subtypes of alcoholics and controls in a homogenous population. C.K. Farren, A.W. Clare, K.F. Tipton and T.G. Dinan. J. Psychiatr. Res. 32, 49-54 (1998). Biochemical and genetic studies on Caucasian subjects with ethanol-induced flushing reaction. R.J Ward, J. McCrodden, K. Tipton, R. Sherwood, J. Keating, T.J. Peters and P. de Witte. Addiction Biology 3, 465-472 (1998). Simultaneous determination of basal and evoked output levels of aspartate, glutamate, taurine and GABA during microdialysis and from superfused brain slice.s. L. Bianchi, L. Della Corte and K.F. Tipton. J. Chromatogr. B 723, 47-59 (1999). Indirect measurement of mitochondrial proton leak and its application. R.K. Porter, O.J.P. Joyce, M.K. Farmer, R. Heneghan, K.F. Tipton, J.F. Andrews, A.M., McBennet, M.D. Lund, C.H/ Jensen and H.P. Melia. Int. J. Obesity 23, 1-7 (1999). Determination of monoamine oxidase activity by hplc with fluorimetric detection. P. Bartolini, K.F. Tipton, L. Bianchi, D. Stephenson, C. Cunningham and L. Della Corte. Neurobiology 7, 159-174 (1999). Involvement of monooxygenases and amine oxidases in hydroxyl radical generation in vivo. M. Strolin Benedetti and K.F. Tipton. Neurobiology 7, 123- 134 (1999). Some Peculiar aspects of monoamine oxidase inhibition. Z. Ben Ramadan, P. Dostert and K.F. Tipton. Neurobiology 7, 159-174 (1999). Potentiation of mitochondrial Ca2+ sequestration by taurine. M.Palmi, G.T. Youmbi, F. Fusi , G.P. Sgaragli, H.B.F.Dixon, M. Frosini and K.F. Tipton. Biochem. Pharmacol. 58, 1123-31 (1999). Development of a continuous, fluorometric coupled enzyme assay for thyrotropin-releasing hormone-degrading ectoenzyme. J.A. Kelly, G. R. Slator, K.F. Tipton, C.H. Williams and K. Bauer. Anal. Biochem. 274, 195-202 (1999). Eukaryotic aldehyde dehydrogenase (ALDDH) genes: human polymorphisms and recommended nomenclature based on divergent evolution and chromosome mapping. V. Vasilou, A. Bairoch, K.F. Tipton and D.W. Nebert. Pharmacogenetics 9, 421-434(1999). Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl. M. Valoti, F. Fusi , M.Frosini, F. Pessina, K.F. Tipton and G.P. Sgaragli. Eur. J. Pharmacol. 391, 199-206 (2000). Taurine-induced attenuation of MPP+ neurotoxicity in vitro: a possible role for the GABA(A) subclass of GABA receptors. M.B. O'Byrne and K.K. Tipton. J. Neurochem. 74, 2087-2093 (2000). Kinetic Investigation of the Specificity of Porcine Brain Thyrotropin-releasing Hormone-degrading Ectoenzyme for Thyrotropin-releasing Hormone-like Peptides. J.A. Kelly, G.R.Slator, K.F. Tipton, C.H. Williams and K. Bauer. J. Biol. Chem. 275, 16746-16751 (2000). A spectrophotometric method for determining the oxidative deamination of methylamine by the amine oxidases. J. M. Lizcano, M. Unzeta and K.F. Tipton. Analyt. Biochem. 286, 75-79 (2000). Time-dependent activation of the semicarbazide-sensitive amine oxidase (SSAO) from ox lung microsomes. J.M. Lizcano, M. Unzeta and K.F. Tipton. Biochem. J. 351, 789-794 (2000). The mitochondrial permeability transition and taurine. M. Palmi, G. Youmbi, G.P. Sgaragli, A. Meini, A Benocci, F. Fusi, M. Frosini, L. Della Corte, G. Davey and K.F. Tipton. Advances in Experimental Medicine and Biology, Vol. 483, pp. 87 - 96. (2000). Effects of ethanol and glutamate agonist infusion on the outflow of sulphoacetaldehyde: Microdialysis studies. S. Capodarca, C.M. Cunningham, P. Bartolini, K.F. Tipton, L. Della Corte, L. Bianchi, R.J. ward, A. Dachour, E. Quertemont, F. Lallemand and P. De Witte. Advances in Experimental Medicine and Biology, Vol. 483, pp. 397 - 304 (2000). Tyrosine-hydroxylase immuno-reactive cells in the rat striatum following treatment with MPP+. M.B. O'Byrne, J.P. Bolam, J.J. Hanley and K.F. Tipton. Advances in Experimental Medicine and Biology, Vol. 483, pp. 369 - 374 (2000). Metabolism of taurine to sulphoacetaldehyde during oxidative stress. C.M. Cunningham and K.F. Tipton. Advances in Experimental Medicine and Biology, Vol. 483, pp. 383 - 388 (2000). Complexities in the neurotoxic actions of 6-hydroxydopamine in relation to the cytoprotective properties of taurine. J. Hayes, K. F. Tipton, L. Bianchi and L Della Corte. Brain Research Bulletin, 55, 239–245 (2001). Oxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinase and nuclear factor kappa B. M. Marangolo, K.F. Tipton, M.M. McGee, D.C. Williams and D.M. Zisterer. Neurotoxicity Res. 3, 397-409 (2001). A study of the in vitro cytotoxicity of a composite resin and compomer C.A. Quinlan, D.M. Zisterer, K.F. Tipton and M.I. O'Sullivan Int. Endod. J. 35, 47-55 (2002). Oxidative stress and radical detection. K.F. Tipton, C. Cunningham and M. Strolin Benedetti. In: Food Antioxidants and Human Health (EC FAIR Conference). (Edited by G. Sgaragli and M. Valoti) pp.47-56, Casa Editrice I Mori, Siena, Italy (2001). Interactions of the neurotoxin 6-hydroxydopamine with glyceraldehyde-3-phosphate dehydrogenase. J.P. Hayes and K. F. Tipton Toxicology Letters 128 197–206 (2002). Immunolocalization of semicarbazide-sensitive amine oxidase in human dental pulp and its activity towards serotonin. M. O’Sullivan, K.F. Tipton and W.E. McDevitt. Arch. Oral Biol. 47, 399-406 (2002). Inhibition of monoamine oxidase modulates the behaviour of semicarbazide-sensitive amine oxidase (SSAO). D. H. Fitzgerald and K. F. Tipton. J. Neural Transm. 109, 251–265 (2002). Rat striatal monoamine oxidase-B inhibition by l-deprenyl and rasagiline: its relationship to 2-phenylethylamine-induced stereotypy and Parkinson's disease. M.B.H. Youdim and K.F. Tipton. Parkinsonism Relat. Disord. 8, 247-253 (2002). Inhibition of the neuronal isoform of nitric oxide synthase significantly attenuates 1-methyl-4-phenylpyridinium (MPP+) toxicity in vitro. M. B. O’Byrne and K. F. Tipton. J. Neural Transm. 109, 585–596 (2002). Semicarbazide-sensitive amine oxidases in pig dental pulp. M. O'Sullivan, M.B. MacDougall, M. Unzeta, J.M. Lizcano and K.F. Tipton. Biochim. Biophys. Acta 1647, 333-336 (2003). The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses. J. O'Sullivan, M. O'Sullivan, K.F. Tipton, M. Unzeta M, M. Del Mar Hernandez and G.P. Davey. Biochim. Biophys. Acta 1647, 367-371 (2003). Activation of human lung semicarbazide sensitive amine oxidase by a low molecular weight component present in human plasma. E. Dalfo, M, Hernandez, J.M. Lizcano, K.F. Tipton and M. Unzeta. Biochim. Biophys. Acta 1638, 278-286 (2003). Oxidative phosphorylation by in situ synaptosomal mitochondria from whole brain of young and old rats. O.J.P. Joyce, M.K. Farmer, K.F. Tipton and R.K. Porter. J. Neurochem. 86, 1032-1041 (2003). Monoamine oxidase inhibitors l-deprenyl and clorgyline protect nonmalignant human cells from ionising radiation and chemotherapy toxicity. C.B. Seymour, C. Mothersill, R. Mooney, M. Moriarty and K.F. Tipton. Br. J. Cancer 89, 1979-1986 (2003). Semicarbazide-Sensitive Amine Oxidases: Enzymes with Quite a Lot to Do. J. O'Sullivan, M. Unzeta, J. Healy. M.I. O'Sullivan, G. Davey and K.F. Tipton. Neurotoxicology 25, 303-315 (2004). Extracellular levels of amino acids and choline in human high grade gliomas: an intraoperative microdialysis study. L. Bianchi, E. De Micheli, A. Bricolo, C. Ballini, M. Fattori, C. Venturi, F. Pedata, K.F. Tipton and L. Della Corte. Neurochem. Res. 29, 325-334 (2004). IntEnz, the integrated relational enzyme database. A. Fleischmann, M. Darsow, K. Degtyarenko, W. Fleischmann, S. Boyce, K.B. Axelsen, A. Bairoch, D. Schomburg, K.F. Tipton and R. Apweiler. Nucleic Acids Res. 32, D434-477 (2004). Monoamine oxidases: certainties and uncertainties K.F. Tipton, S. Boyce, J. O'Sullivan, G.P. Davey and J. Healy. Current Med. Chem. 11,1965-1982 (2004). Taurine prevents streptozotocin impairment of hormone-stimulated glucose uptake in rat adipocytes. M.A. Colivicchi, L Raimondi, L. Bianchi, K.F. Tipton, R. Pirisino and L. Della Corte. Eur. J. Pharmacol. 495, 209-215 (2004). Electrochemical investigation into the redox activity of Fe(II)/Fe(III) in the presence of nicotine and possible relations to neurodegenerative diseases. M.H. Bridge, E. Williams, M.E. Lyons, K.F. Tipton and W. Linert. Biochim. Biophys. Acta 1690, 77-84 (2004). The effects of two salsolinol derivatives on mitochondrial respiration and the likely nature of any endogenous parkinsonism-inducing toxin.M.K. Farmer, K.F. Tipton and G.P. Davey. Design of Monoamine oxidase Inhibitors and their role in neurotransmission (drug development). (Edited by T.L..Török & I. Klebovich) pp.55-77, Medicina Publishing House Co., Budapest, Hungary (2004). Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori. B. Mee, D. Kelleher, J. Frias, R. Malone, K.F. Tipton, G.T. Henehan and H.J. Windle. FEBS J. 272, 1255-1264 (2005) Structure-activity studies with high affinity inhibitors of pyroglutamyl-peptidase II. J.A. Kelly, G.A. Scalabrino, G.R. Slator, A.A. Cullen, J.F. Gilmer, D.G. Lloyd, G.W. Bennett , K. Bauer, K.F. Tipton and C.H. Williams. Biochem. J. Mar 31(2005); [Epub ahead of print] Educational, reviews & books MAO – The Mother of all Amine Oxidases. J.P.M. Finberg, M.B.H. Youdim, P. Riederer and K.F.Tipton (Editors), pp. xix plus 355. Springer-Verlag, Vienna, Austria (1998). Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics. M. Strolin Benedetti and K.F. Tipton. J. Neural Transm. (Suppl.) 52, 149-171 (1998). Kinetics for the numerically challenged. A.G. McDonald and K.F. Tipton. The Biochemist 21, 18-23 (1999). Trait markers for alcoholism: clinical utility. C.K. Farren and K.F. Tipton. Alc. Alcoholism 34, 649-665 (1999). Monoamine oxidases (MAO): Functions in the nervous system. K.F. Tipton, E.M. O'Brien and M.B.H. Youdim. In: Encyclopedia of Neuroscience, 2nd Edition (Edited by G. Adelman and B. Smith). Elsevier Science BV, Amsterdam (1999) Mitochondria, cell death and DNA damage. G.P. Davey and K.F. Tipton. Radiation Research 2, 390-394 (2000). Inhibitors of monoamine oxidase and the pressor response to dietary amines. K.F. Tipton In: Milestones in Monoamine Oxidase Research: Discovery of (-)-Deprenyl. (Edited by K. Magyar and E.S. Vizi) pp. 19-32, Medicina Publishing House Budapest, Hungary (2000). Taurine 4: Taurine and Excitable Tissues. L. Della Corte, R. J. Huxtable, G.P. Sgaragli and K. F. Tipton (Editors). Advances in Experimental Medicine and Biology, Vol. 483, pp. 1 - 664, Kluwer Academic/Plenum Publishers, Dordrecht, The Netherlands (2000). Enzyme Classification and Nomenclature. K.F. Tipton and S. Boyce. In: Nature Encyclopedia of Life Sciences. Nature Publishing Group, London: http://www.els.net/ [doi:10.1038/npg.els.0000710] (2000). Monoamine oxidase assays. K.F. Tipton, G. Davey and M. Motherway. In: Current Protocols in Pharmacology. (Edited by S.J. Enna, M. Willias , J. W. Ferkany, T, Kenakin, R. E. Porsolt and J.P. Sullivan) John Wiley New York pp. .3.6.1-3.6.42 (2000). History of the enzyme nomenclature system. S. Boyce and K.F. Tipton. Bioinformatics 16, 34-40 (2000). Amine Oxidases and the metabolism of xenobiotics. . K.F. Tipton and M. Strolin Benedetti. In: Enzyme Systems that Metabolise Drugs and Other Xenobiotics. (Edited by C. Ioannides) pp.95 –146, John Wiley & Sons, Ltd, Chichester, UK (2001). Metabolic systems and the behaviour of neuronal systems. A.G. McDonald, S. Boyce, J. Connolly, T. Kazic, W. Wise and K.F. Tipton. Proceedings of the First World Congress of Neuroinfomatics. (Edited by F. Rattay) pp. 308-316, Argesima/ASIM Verlag, Vienna, Austria (2001). Enzymes: Irreversible Inhibition. K.F. Tipton In: Nature Encyclopedia of Life Sciences. Nature Publishing Group, London. http://www.els.net/ [doi:10.1038/npg.els.0000601] (2001). Principles of enzyme assay and kinetic studies. K.F. Tipton. In: Enzyme Assays: A Practical Approach (Edited by R, Eisenthal and M.J. Danson) pp. 1-47, Oxford University Press (2002). Biogenic amines. diet and the properties of amine oxidases. K.F. Tipton. In: Biogenically Active Amines in Food. (Edited by D.M.L. Morgan, T. Hirvi, G. Dandrifosse, P. Deloyer and A. White) COST 917, vol. 6 pp. 117-121, European Communities Publication Office, Brussels , Belgium (2002). Kinetics of Catalyzed Reactions – Biological. A. G. McDonald and K.F. Tipton. In: Encyclopedia of Catalysis (Edited by I.T. Horváth), John Wiley & Sons, Inc. http://www.mrw.interscience.wiley.com/enccat/ (DOI: 10.1002/0471227617.eoc127) In: Encyclopedia of Catalysis, vol. 4 (Edited by I.T. Horváth), John Wiley & Sons, Inc., pp 395-471 (2003). The use of taurine analogues to investigate taurine functions and their potential therapeutic applications. L. Della Corte, R.R. Crichton, G. Duburs, K. Nolan, K.F. Tipton, G. Tirzitis and R.J. Amino Acids 23, 367-379 (2002). It can be a complicated life being an enzyme. K.F. Tipton, M.P. O'Sullivan, G.P. Davey and J. O'Sullivan. Biochem. Soc. Trans. 31, 711-715 (2003). Affinity precipitation methods. J.A. Irwin and K.F. Tipton. Methods Mol Biol. 244, 205-224 (2004). Monoamine oxidases (MAO): Functions in the nervous system. K.F. Tipton, J. O'Sullivan and M.B.H. Youdim. In: Encyclopedia of Neuroscience, 3rd Edition. (Edited by G. Adelman and B. Smith). CD ROM, ISBN: 0444514325, Elsevier Science BV, Amsterdam. (2004). Extending enzyme classification with metabolic and kinetic data: Some difficulties to be resolved. S. Boyce, K.F. Tipton and A.G. McDonald. Proceedings of the 1st International Beilstein Workshop on Experimental Standard Conditions of Enzyme Characterizations. (Edited by M.G. Hicks & C. Kettner) pp. 17-43, Beilstein Institut, Frankfurt, Germany (2004). The importance of uniformity in reporting protein-function data. R. Apweiler, A. Cornish-Bowden, J.H. Hofmeyr, C. Kettner, T.S. Leyh, D. Schomburg and K. Tipton. Trends Biochem. Sci. 30, 11-12 (2005). Amine Oxidases and Drug Metabolism. K.F. Tipton and M. Strolin Benedetti. In: Proc 15th Int Symp Microsomes and Drug Oxidations, Mainz Germany. (Edited by F. Oesch), pp 47-54 Merimond S.r.l., Bologna, Italy (2005). Further information on the Neurochemistry, Enzymology and Systems Biology Group |
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Last updated: Aug 04 2006.
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