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Publications

IMMUNE REGULATION RESEARCH GROUP

Prof Kingston Mills

  1. McGuirk, P. McCann and Mills, K.H.G. (2002) Pathogen-specific T regulatory 1 (Tr1) cells induced in the respiratory tract by a bacterial molecule that stimulates IL-10 production by dendritic cells: a novel strategy for evasion of protective Th1 responses against Bordetella pertussis. J. Exp. Med. 195, 221-231.


  2. McGuirk P. and Mills, K.H.G. (2002) Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases. Trends Immunol. 23, 450-455.


  3. Kelly, A., Vereker, E., Brady, M., Brooks, C., Loscher, C, Mills, K.H.G. and Lynch, M.A. (2003) Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1b induced inhibition of long term potentation in the rat dentate gyrus. J. Biol Chem. 278, 19453-62.


  4. Lavelle, E., McNeela, E., Armstrong, M., Leavy, O., Higgins , S.C. and Mills K.H.G. (2003) Cholera toxin promotes the induction of regulatory T cells by modulation dendritic cell activation. J. Immunol. 171, 2384-2392.


  5. Higgins, S., Lavelle, E., McCann, C., Keogh, B., McNeela, E, Byrne, P., O’Gorman, B., Jarnicki, A., McGuirk, P. and Mills, K.H.G. (2003) Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J. Immunol. 171, 3119-3127.


  6. Brady, M. MacDonald, A., Rowan, A. and Mills K.H.G. (2003) Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes. Eur. J. Immunol. 33, 3448-3457.


  7. McNeela, E., Jabbal-Gill, E. Illum, L., Pizza, Rappuoli, R., Podda, A., Lewis, D.M.and Mills, K.H.G. (2004) Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: correlation between toxin neutralizing antibody and Th2 responses. Vaccine 22, 909-914.


  8. Lavelle, E., Jarnicki, A., McNeela, E., Armstrong, M., Leavy, O., Higgins, S. and Mills, K.H.G. (2003) Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent. J. Leuc. Biol. 33, 3448-3357.


  9. Ross, P.J., Lavelle, E.C., Mills, K.H.G. and A.P. Boyd. (2004). Adenylate cyclase toxin from Bordetella pertussis synergises with lipopolysaccharide to promote innate IL-10 production and enhance the induction of Th2 and regulatory T cells. Infect. Immun.72 , 1568-1579.


  10. Mills, K.H.G. and McGuirk, P. (2004). Antigen-specific regulatory T cells – their induction and role in infection. Seminars in Immunology16 (2), 107-117.


  11. Bowe, F., Lavelle, E.C., McNeela, E. A., Hale, C., Clare, S., Arico, B., Giuliani, M.M., Rae, A., Huett, A., Rappuoli, R., Dougan, G. and Mills, K. H.G. (2004) Mucosal vaccination against serogroup B meningococcus:Induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin. Infect. Immun. 72, 4052-4060.


  12. Byrne, P., McGuirk, P., Todryk, S. and Mills, K.H.G. (2004) Depletion of NK cells results in disseminating lethal infection with Bordetella pertussis associated with a reduction of antigen-specific Th1 and enhancement of Th2, but not Tr1 cells. Eur. J. Immunol 34, 2579-2588.


  13. Mills, K.H.G. (2004) Regulatory T cells: friend or foe in immunity to infection. Nature Rev. Immunol. 4, 841-55.


  14. Nolan, Y., Maher, F.O., Martin, D.S. Lonergan, P.E., Kavanagh, T., Clarke, R. Brady, M.T., Bolton, A.E., Mills, K.H.G. and Lynch, M.A. (2004) Role of IL-4 in regulation of age-related inflammatory changes in hippocampus. J. Biol. Chem. 280, 9354-62.


  15. Daly, L.M., Johnson, P.A., Nicolson, C., Robertson, J. and Mills, K.H.G. (2005) Innate IL-10 promotes the induction of Th2 responses with plasmid DNA expressing HIV gp120. Vaccine 23, 963-74.


  16. Boyd, A.P., Ross, P.J., Conroy, H., Mahon, N Lavelle, E.C.and Mills, K.H.G. (2005) Bordetellapertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death. J. Immunol. 175: 730-738.


  17. Noone, C.M. Lewis, E., Frawely, A.B., Newman, R.W., Mahon , B.P., Mills, K.H.G. and Johnson, P.A. (2005) Novel mechanism of immunosuppression by influenza virus haemagglutinin: selective suppression of IL-12p35 transcription in murine bone marrow derived dendritic cells. J. Gen. Virol.86: 1885-90


  18. Armstrong, M.E., Lavelle, E.C., Loscher, C.E., Lynch, M.A. and Mills, K.H.G. (2005) Induction of proinflammatory responses in the murine hypothalamus following intranasal delivery of cholera toxin: implications for the use of AB toxins as adjuvants in nasal vaccines. J. Infec Dis 192: 1628-33.


  19. Loscher, CL Leavy, O. Kelleher, D, *Mills, K.H.G and *Roche, H.M. (*authors contributed equally). (2005) Conjugated linoleic acid suppresses NF k B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction. J. Immunol 175:4990-4998.


  20. Lelivelt, C.L., McCabe, M.S., Newell, C.A., Desnoo, C.B., vanDun, K.M., Birch-Machin, I., Gray, J.C., Mills, K.H.G., Nugent, J.M. (2005) Stable Plastid Transformation in Lettuce (Lactuca sativa L.) Plant Mol. Biol. 58, 763-74.


  21. Huo, Z., Sinha, R., McNeela, E.A. Borrow, R., Giemza, R., Cosgrove, C., Heath, P., Mills, K.H.G. Rappuoli, R., Griffin, G.E. and Lewis, D.J.M. (2005) Induction of protective serum meningococcal bactericidal and diphtheria-neutralizing antibodies and mucosal IgA in volunteers by nasal insufflations of Nisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with chitosan. Infect Immun 73, 8255-65.


  22. Mills, K.H.G. and Boyd, A (2005). Evasion of immune responses by bacteria. In: Topley and Wilson ’s Microbiology and Microbial Infections: Immunology Volume, Eds S. Kaufmann and M. Steward, Edward Arnold Publishers Ltd, London pp 645-674.


  23. Brady, M.T., McGuirk, P. and Mills, K.H.G. (2006) Suppression of immune responses by bacteria and their products through dendritic cell modulation and regulatory T cell induction. In: Dendritic cell interactions with bacteria. Ed M. Resigno. Cambridge University press. pp193-221.


  24. Lipinski, K.S., Pelech, S., Mountain, A., Irvine, A.S., Kraaij, R., Bangma, C.H., Mills, K.H.G. and Todryk S.M. (2006) Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity. Cancer Immunol Immunother 55 (3): 347-54.


  25. Stephenson, I., Nicholson, K.G. Rudin, A. Colegate, A., Podda, A. Bugarini, R., del Giudice, G., Minutello, A., Bonnington, S., Holmgren, J., Mills, K.H.G, and Zambon, M.C. (2006) Trivalent nasal inactivated influenza vaccine with non-toxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants: a randomised phase I trial. J. Virol. 80 (10):4962-70.


  26. Jarnicki, A.G., Lysaght, J, Todryk, S, Mills, K.H.G. (2006) Suppression of antitumor immunity by IL-10 and TGF-b-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells. J Immunol177 (2): 896-904.


  27. Sutton, C, Keogh, B., Brereton, C., *Mills, K.H.G. and *Lavelle, E.C. (*authors contributed equally) (2006) A crucial role for IL-1 in the induction of IL-17 producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203(7):1685-91.


  28. Higgins, S., Jarnicki, A, Lavelle, E.C. and Mills, K.H.G. (2006) TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells. J. Immunol. 177:7980-7989.


  29. Braat, H, McQuirk, P., Ten Kate F.J.W., Huibregtse, I., Dunne, P, Hommes, D.W., Deventer, S and Mills, K.H.G. (2006) Prevention of experimental colitis by parenteral administration of a pathogen derived immunomodulatory molecule. Gut 56, 351-357.


  30. Lavelle, E., Leavy, O., Mills, K.H.G. (2007) Modified Bacterial toxins. In: Vaccine Adjuvants: Immunological and Clinical Principles. Eds D. Harn and C.J Hackett. Humana Press. pp 113-155.


  31. Lysaght, J., Jarnicki, A. and Mills, K.H.G. (2007) Reciprocal effects of Th1 and Treg cell inducing pathogen-associated immunomodulatory molecules on anti-tumour immunity. Cancer Immunol Immunother.56, 1367-1379.


  32. Lyons, A., Downer, E., Crotty, S., Nolan, Y.M. Mills, K.H.G. and Lynch, M.A. (2007) CD200 ligand-receptor interaction modulates microglial activation in vitro and in vivo: a role for IL-4. J. Neuroscience. 27 (31): 8309-13.


  33. Fennelly, N.F., Sisti, F, Higgins, S.C., Ross, P., van der Heide, H. Mooi, F.R., Boyd, A.P. and Mills, K.H.G. (2008) Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses. Infect. Immun. 76(3), 1257-1266.


  34. Conroy, H. Marshall, N.A. and Mills, K.H.G. (2008) TLR ligand suppression or enhancement of Treg cells – A double edged sword in immunity to tumors. Oncogene 27( 2): 168-80.


  35. Jarnicki, AJ, Conroy, H. Brereton, C, , Donnelly, G., Toomey, D., Walsh, K.,, Sweeney, C., Leavy, O., Fletcher, J., Lavelle, E., Dunne, P. and Mills, K.H.G. (2008) Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics. J. Immunol 180 (6): 3797-806.


  36. Rowan, A.G., Fletcher, J, Ryan, E.J. Moran, B. Hegarty, J. E., O’Farrelly, C. and Mills, K.H.G. (2009) Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-b . J. Immunol 181(7): 4485-94.


  37. Costelloe, C., Murphy, A., Armstrong, M., Loscher, C., Dunne, E., McQuillan, K., O’Neill, L., Montavani, A., *Mills K.H.G and *Lynch M.A. (*equal contribution). (2008) IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8 J. Neurochem 105( 5): 1960-9.


  38. Hickey, F. and Mills, K.H.G. (2008) Adenylate cycalse toxin from Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells. Journal of Leukocyte Biology 84( 1): 234-43.


  39. Dunne, P.J. Rowan, A.G., Fletcher, J.M. and Mills, K.H.G. (2008) IL-10 and TGF-b -producing regulatory T cells in infection. In Regulatory T Cells and Clinical Application. Ed. Shuiping Jiang, Springer Science and Business Media, LLC pp 423-453.


  40. Downer, E.J., Cowley, A.R., Lyons, A., Mills, K.H.G., Berezin, V., Bock, E. and Lynch, M.A. The NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory effects in the hippocampus of the aged rat. Neurobiology of Ageing. 2008 May 9. [Epub ahead of print] PMID: 18468731


  41. Toomey, D, Jarnicki, A, Conroy, H. and Mills, K.H.G. (2008) Therapeutic vaccination with dendritic cells pulsed with tumor-derived HSP70 and a COX-2 inhibitor induced protective immunity against B16 melanoma. Vaccine 2 6: 3540-9.


  42. Mills, K.H.G. (2008) Induction, function and regulation of IL-17-producing T cells. Eur J. Immunol. 38, 2636-2649.


  43. Mills K.H.G. (2008) TLR9 turns the tide on Treg cells. Immunity29, 518-520.


  44. Rowan, A.G., Fletcher, J, Ryan, E.J. Moran, B. Hegarty, J. E., O’Farrelly, C. and Mills, K.H.G. (2009) Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGFb . J. Immunol 181( 7): 4485-94.


  45. Mills, K.H.G. (2009) Designer adjuvants for enhancing the efficacy of infectious disease and cancer vaccines based on suppression of regulatory T cell induction. Immunol Letts 122 , 108-111.


  46. Curtin, N.H., Mills, K.H.G. and Connor, T.J. (2009) Psychological stress increases expression of IL-10 and its homolog IL-19 via beta-adrenoceptor activation: Reversal by the anxiolytic chlordiazepoxide. Brain, Behavior, and Immunity 23 (3), 371-379.


  47. de Roos, B. Rungapamestry, V., Ross, K. Rucklidge, G. Reid, M.Duncan, G. Horgan, G. Toomey, S. Browne, J. Loscher, C, Mills, K.H.G. and Roche, H.M (2009) Attenuation of inflammation and cellular stress related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout (IL-1RI-/-) mice on a high-fat diet. Proteomics 9, 3244-3256.


  48. Curtin , N.H. , Boyle, N.T., Mills, K.H.G. and Connor, T.J. (2009) Psychological stress suppresses innate IFN-g production via glucocorticoid receptor activation: Reversal by the anxiolytic chlordiazepoxide. Brain, Behavior, and Immunity 23 (4):535-547.


  49. Dunne, P.J., Moran, B., Cummins, R.C. and Mills, K.H.G. (2009) CD11c+CD8a+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis. J. Immunol 183, 400-410.


  50. Brereton, C.F., Sutton, C.E., Lavelle, E. C. and Mills, K.H.G. (2009) Inhibition of ERK MAP kinase suppresses IL-1b and IL-23-driven IL-17 production and attenuates autoimmune disease. J. Immunol 183(3):1715-23.


  51. Walsh, K.*, Brady, M.T*, Finlay, C., Boon, L. and Mills, K.H.G. (*authors contributed equally). (2009). Infection with a helminth parasite attenuates autoimmunity through TGF-b mediated suppression of Th17 and Th1 responses. J. Immunol 183(3):1577-86.


  52. Lyons . A,, McQuillan, K., Deighan, B.F., O'Reilly, J.A., Downer, E.J., Murphy, A.C., Watson, M., Piazza, A., O'Connell, F., Griffin, R., Mills, K.H. and Lynch, M.A. (2009) Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide. Bra in Behav Immun. 23(7):1020-7.


  53. Sutton, CE*. Lalor, SJ*, Sweeney, C, Brereton, C, Lavelle, E.C. and Mills, K.H.G. (*authors contributed equally). (2009) IL-1b and IL-23 promote innate IL-17 production by g d T cells which amplifies Th17 responses and autoimmunity. Immunity 31 (2):331-41.


  54. Fletcher, J.M., Lonergan, R., Costelloe, L., Kinsella, K., Moran, B. TO' Farrrelly, C. Tubridy, N. and Mills, K.H.G. (2009) CD39 + Foxp3 + regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J. Immunol. 183 (11):7602-7610.


  55. Reynolds , C.M. Draper, E. Keogh, B. Rahman, A. Moloney, A.P. Mills, K.H.G ., Loscher, C. and Roche, H.M. (2009). A high-conjugated linoleic acid enriched beef diet attenuates LPS-induced inflammation in part through PPARg mediated suppression of TLR4. J. Nutrition 139 (12):2351-7.


  56. Mills, K.H.G. and Dunne, A. (2009) IL-1, master mediator or initiator of inflammation. Nature Medicine, 15 (12):1363-4.


  57. McQuillan, K. L, Lynch, M.A and Mills, K.H.G . (2010) Activation of microglia by Ab-specific Th1 and Th17 cells and its regulation by Th2 cells. Brain Behaviour and Immunity 24(4):598-607.


  58. Murphy, A.C, Lalor, SJ, Lynch, M.A and Mills, K.H.G . (2010) Infiltration of Th1 and Th17 cells and activation of microglia in the brain during the course of experimental autoimmune encephalomyelitis. Brain Behaviour and Immunity 24(4):641-51.


  59. Downer, E.J., Cowley, A.R., Lyons, A., Mills, K.H.G. , Berezin, V., Bock, E. and Lynch, M.A. (2010) The NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory effects in the hippocampus of the aged rat. Neurobiology of Ageing. 31, 118-128.


  60. McGuirk, P., Higgins, S.C. and Mills K.H.G. (2010) The role of regulatory T cells in respiratory infections and asthma and allergy. Curr Allergy Asthma Rep. 10(1):21-8.


  61. Higgins, S.C. and Mills K.H.G. (2010) TLR and NLR agonists and other immunomodulatrors as infectious diseases vaccine adjuvants. Curr. Infect. Dis. Rep. Curr Infect Dis Rep 12 :4 - 12.


  62. Dunne, A., Ross, P.J. Pospisilova, E., Masin, J, Meaney, A., Sutton, C.E., Tschopp, J. Sebo, P. and Mills, K.H.G . (2010) Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis. J. Immunol 185(3):1711-9.


  63. Masters, S.L., Mielke, L.A. Cornish, A.L., Sutton, C.E., Cengia, L., Roberts, A.W., Wicks, I.P. Mills, K.H.G. and Croker, B.A. (2010) IFN-g promotes IL-1b production from human cells but inhibits IL-1b and IL-17 production from mouse cells. EMBO Rep. 11(8):640-6.


  64. O'Brien, M, Lonergan R, Costelloe L., O'Rourke, K., Kinsella, K., Fletcher J.M., Kinsella, K, Sweeney, C., Antonelli, G., Mills K.H., O'Farrelly C., Hutchinson, M. and Tubridy N (2010) OAS1: a multiple sclerosis susceptibility gene which influences disease severity. Neurology 75(5):411-8.


  65. Fletcher, J.M. Lalor, S.J., Sweeney, C.M., Tubridy, N. and Mills, K.H.G . (2010) T cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Clin. Exp Immunol; 162(1):1-11.


  66. Masters, S.L., Dunne, A., Subrahmanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., Mullooly, N., Mielke, L.A., Harris, J., Coll, R., Mills, K.H.G., Mok, K.H., Newsholme, P., Nunez, G., Yodoi, J., Kahn, S.E., Lavelle E.C., O'Neill, L.A.J. (2010). Activation of the Nlrp3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1b in type 2 diabetes. Nature Immunology 11(10):897-904.


  67. Coleman, M.M., Keane, J., Mills, K.H.G. (2010) Editorial: Tregs and BCG - dangerous liaisons in TB. J. Leukoc. Biol. 88(6):1067-9.


  68. Draper E, Reynolds CM, Canavan M, Mills KHG , Loscher CE, Roche HM (2010) Omega-3 fatty acids attenuate dendritic cell function via NF-kB independent of PPARg. J. Nutr. Biochem. 22(8):784-90.


  69. Sweeney, CM, Lonergan, R, Basdeo, S.A., Dungan, LS, Kinsella, K. Costelloe, L. Tubridy, N, * Mills, K.H.G. and *Fletcher, J.M. (2011) IL-27 mediates the response to IFN- b therapy in multiple sclerosis patients. Brain Behaviour & Immunity. 25(6):1170-81. *Equal contribution


  70. Lalor, S.J., Dungan, L. Sutton, C., Basdeo, S.A. Fletcher, J.M. and Mills, K.H.G. (2011). Caspase-1 processed cytokines IL-1b and IL-18 promote IL-17-production by gd and CD4 T cells that mediate autoimmunity. J. Immunol 186(10):5738-48.


  71. Brereton, C.F., Sutton, C.E., Ross, P.J. Iwakura, Y. Pizza, M. Rappuoli, R. Lavelle, E.C. Mills, K.H.G. (2011). Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection via activation of IL-1 and IL-23. J. Immunol 186:5896-906.


  72. Dunne, A., Marshall, N.A., and Mills, K.H.G (2011). TLR based therapeutics. Curr Opin Pharmacol 11:404-411.


  73. McLoughlin, R.M. and Mills K.H.G. (2011) Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma. The Journal of Allergy and Clinical Immunology. 127(5):1097-107.


  74. Dungan, L.S., and Mills, K.H.G (2011). Caspase-1-processed IL-1 family cytokines play a vital role in driving innate IL-17. Cytokine. 56(1): 126-32.


  75. Byrne, W. L., Mills, K. H., Lederer, J. A. and O'Sullivan, G. C., Targeting regulatory T cells in cancer. Cancer Res 2011. 71: 6915-6920.


  76. Draper, E., Reynolds, C. M., Canavan, M., Mills, K. H ., Loscher, C. E. and Roche, H. M., Omega-3 fatty acids attenuate dendritic cell function via NF-kappaB independent of PPARgamma. J Nutr Biochem 2011. 22: 784-790.


  77. McGillicuddy, F. C., Harford, K. A., Reynolds, C. M., Oliver, E., Claessens, M., Mills, K. H . and Roche, H. M ., Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis. Diabetes 2011. 60: 1688-1698.


  78. McLoughlin, R. M. and Mills, K. H., Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma. J Allergy Clin Immunol 2011. 127: 1097-1107; quiz 1108-1099.


  79. Mills, K. H., TLR-dependent T cell activation in autoimmunity. Nat Rev Immunol 2011. 11 : 807-822.


  80. Sisti, F., Fernandez, J., Higgins, S. C., Casabuono, A., Couto, A., Mills, K. H. and Hozbor, D., A deep rough type structure in Bordetella bronchiseptica lipopolysaccharide modulates host immune responses. Microbiol Immunol 2011. 55: 847-854.


  81. Sweeney, C. M., Lonergan, R., Basdeo, S. A., Kinsella, K., Dungan, L. S., Higgins, S. C., Kelly, P. J., Costelloe, L., Tubridy, N., Mills, K. H. and Fletcher, J. M., IL-27 mediates the response to IFN-beta therapy in multiple sclerosis patients by inhibiting Th17 cells. Brain Behav Immun 2011. 25: 1170-1181.


  82. Allen, A. C., Kelly, S., Basdeo, S. A., Kinsella, K., Mulready, K. J., Mills, K. H., Tubridy, N., Walsh, C., Brady, J. J., Hutchinson, M. and Fletcher, J. M., A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers. Mult Scler 2012.


  83. Coleman, M. M., Finlay, C. M., Moran, B., Keane, J., Dunne, P. J. and Mills, K. H., The immunoregulatory role of CD4(+) FoxP3(+) CD25(-) regulatory T cells in lungs of mice infected with Bordetella pertussis. FEMS Immunol Med Microbiol 2012. 64: 413-424.


  84. Conroy, H., Galvin, K. C., Higgins, S. C. and Mills, K. H., Gene silencing of TGF-beta1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells. Cancer Immunol Immunother 2012. 61: 425-431.


  85. Cunningham, C. C., Mills, E., Mielke, L. A., O'Farrell, L. K., Lavelle, E., Mori, A., McCarthy, G. M., Mills, K. H. and Dunne, A., Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase. Clin Immunol 2012. 144: 228-236.


  86. Higgs, R., Higgins, S. C., Ross, P. J. and Mills, K. H., Immunity to the respiratory pathogen Bordetella pertussis. Mucosal Immunol 2012. 5: 485-500.


  87. Lynch, M. A. and Mills, K. H., Immunology meets neuroscience--opportunities for immune intervention in neurodegenerative diseases. Brain Behav Immun 2012. 26: 1-10.


  88. Marshall, N. A., Galvin, K. C., Corcoran, A. M., Boon, L., Higgs, R. and Mills, K. H., Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-gamma+IL-17+ polyfunctional T cells that mediate rejection of murine tumors. Cancer Res 2012. 72: 581-591.


  89. Morine, M. J., Toomey, S., McGillicuddy, F. C., Reynolds, C. M., Power, K. A., Browne, J. A., Loscher, C., Mills, K. H. and Roche, H. M., Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice. J Nutr Biochem 2012.


  90. Peral de Castro, C., Jones, S. A., Ni Cheallaigh, C., Hearnden, C. A., Williams, L., Winter, J., Lavelle, E. C., Mills, K. H. and Harris, J., Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion. J Immunol 2012.


  91. Pindjakova, J., Hanley, S. A., Duffy, M. M., Sutton, C. E., Weidhofer, G. A., Miller, M. N., Nath, K. A., Mills, K. H., Ceredig, R. and Griffin, M. D., Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction. Kidney Int 2012. 81: 379-390.


  92. Reynolds, C. M., McGillicuddy, F. C., Harford, K. A., Finucane, O. M., Mills, K. H. and Roche, H. M., Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. Mol Nutr Food Res 2012. 56: 1212-1222.


  93. Sutton, C. E., Mielke, L. A. and Mills, K. H., IL-17-producing gammadelta T cells and innate lymphoid cells. Eur J Immunol 2012. 42: 2221-2231.

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