| | |
|
Main Navigation
|
|
Secondary Navigation
|
PublicationsCANCER DRUG DISCOVERY GROUPProf Clive WilliamsElmes RB, Orange KN, Cloonan SM, Williams DC, Gunnlaugsson T, Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents., Journal of the American Chemical Society, 2011, 133(40),15862-15865 O'Boyle, N.M., Knox, A.J.S., Price, T.P., Williams, D.C., Zisterer, D.M., Lloyd, D.G., Meegan, M.J., Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90, Bioorganic & Medicinal Chemistry, 19, (20), 2011, p6055-6068 Maginn EN, Browne PV, Hayden P, Vandenberghe E, McDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. British Journal of Cancer, 2011, 104, 281-9 Yvonne M. McNamara, Suzanne M. Cloonan, John J. Keating, Stephen G. Butler, Günther H. Peters, Mary J. Meegan and D. Clive Williams Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents. Bioorganic & Medicinal Chemistry, 2011, 19, 1328-1348 Robert B. P. Elmes, Marialuisa Erby, Suzanne M. Cloonan, Susan J. Quinn, D. Clive Williams and Thorfinnur Gunnlaugsson, Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation. Chemical Communications, 2011, 47, 686-8 Forde JC., Maginn EN., McNamara G., Martin LM., Campiani C., Williams DC , Zisterer D., McElligott AM., Lawler M., Lynch TH, Hollywood D., Marignol L Microtubule-Targeting-Compound PBOX-15 Radiosensitizes Cancer Cells In Vitro. Cancer Biology and Therapy, 2011, 421-428 Cloonan, S.M. and Williams, D.C., The antidepressants maprotiline and fluoxetine induce Type-II autophagic cell death in drug resistant Burkitt's lymphoma, International Journal of Cancer, 2011, 128, 1712-23 Nathwani, S, Cloonan, S.M., Stronach, M, Campiani, G, Lawler, M, Williams, D.C. and Zisterer, D.M. Novel Micro-tubule targetting agents, pyrrolo-1,5-benzoxazepines induce cell cycle arrest and apoptosis in prostate cancer cells, Oncology Reports, 2010, 24, 1499-1507 Yang, Yidong; Carta, Giorgio; Peters, Martin; Price, Trevor; O'Boyle, Niamh; Knox, Andrew; Fayne, Darren; Williams, D.C.; Meegan, Mary; Lloyd, David, TieredScreen – layered virtual screening tool for the identification of novel Estrogen Receptor Alpha modulators, Molecular Informatics 2010 29, 421-430 Onnis, Valeria; Kinsella, Gemma; Carta, Giorgio; Jagoe, William; Price, Trevor; Williams, Clive; Fayne, Darren; Lloyd, David, Virtual Screening for the identification of novel non-steroidal Glucocorticoid Modulators, Journal of Medicinal Chemistry, 2010 53, 3065-3074 S A Bright, A M McElligott, J W O'Connell, L O'Connor, P Carroll, G Campiani, M W Deininger, E Conneally, M Lawler, D C Williams, and D.M Zisterer, 1.Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo, British Journal of Cancer, 2010, 102, 1474-1482 Sandra A. Bright, Giuseppe Campiani, Michael W. Deininger, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment, Biochemical Pharmacology, 2010, 80, 31-38 Suzanne M. Cloonan, John J. Keating, John E. O'Brien, Desmond Corrigan, Pierce V Kavanagh, D. Clive Williams and Mary J. Meegan, Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulphur substituted a-alkylthioamphetamines, Bioorganic and Medicinal Chemistry, 2010, 18, 4009-4031 Cloonan SM, Drozgowska A, Fayne D and Williams DC, The antidepressants maprotiline and fluoxetine have potent antiproliferative effects against Burkitt's lymphoma independently of the norepinephrine and serotonin transporters, Leukemia and Lymphoma, 51, (3), 2010, p523 - 539 Nathwani, S-M., Butler, S., Meegan, M.J., Campiani, G., Lawler, M., Williams , D.C. & Zisterer, D.M., Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines., Cancer Chemotherapy and Pharmacology, 65, (2), 2010, p289-300 McElligott, AM, Maginn, EN, Greene, LM, McGuckin, S, Hayat, A, Browne, PV, Butini, S, Campiani, G, Catherwood, MA, Vandenberghe, E, Williams, DC, Zisterer, DM, Lawler, M, The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia., Cancer Research, 69, (21), 2009, p8366 - 8375 Nathwani,SM, Butler, S, Fayne,D, McGovern,NN, Sarkardi,B, Meegan,MJ, Lloyd,DG, Campiani,G, Lawler,M, Williams,DC, and Zisterer, DM, Novel Microtubule targetting agents, pyrrolo-1,5,benzoxazepines induce apoptosis in multi-drug-resistant cancer cells, Cancer Chemother Pharmacol, 2009, 65, 289-308 Cloonan, SM, Keating, JJ, Butler, SG, Knox, AJ, Jørgensen, AM, Peters, GH, Rai, D, Corrigan, D, Lloyd, DG, Williams, DC, Meegan, MJ, Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents., European Journal of Medicinal Chemistry, 44, 2009, p4862 - 4888 Bane, F.T., Pennington, S.R., Campiani, G., Williams, D.C., Zisterer, D.M. & Mc Gee, M.M., The microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1, in malignant hematopoietic cells., Journal of Pharmacology and Experimental Therapeutics, 329, 2009, p38-47 Bright S.A., Greene, L.M., Greene, T.F., Campiani, G., Buitini, S., Brindisi, M., Lawler, M., Meegan, M.J., Williams, D.C. and Zisterer, D.M. , The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells, Biochemical Pharmacology, 77, (3), 2009, p310-321 Verma NK, Dempsey E, Conroy J, Olwell P, Mcelligott AM, Davies AM, Kelleher D, Butini S, Campiani G, Williams DC, Zisterer DM, Lawler M, Volkov Y., A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin., Journal of Molecular Medicine , 86, (4), 2008, p457-469 Greene, LM, Campiani, GC, Lawler, M, Williams, DC and Zisterer, DM, BubR1 is Required for a Sustained Mitotic Spindle checkpoint arrest in Human Cancer cells treated with a tubulin-targetting pyrrolo-1,5-benzoxazepine, Molecular Pharmacology, 73, (2), 2008, p419 - 430 Greene LM, Kelly L, Onnis V, Campiani G, Lawler M, Williams DC, Zisterer DM., STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells., Journal of Pharmacology and Experimental Therapeutics, 321, (1), 2007, p288-297 Knox AJ, Meegan MJ, Sobolev V, Frost D, Zisterer DM, Williams DC, Lloyd DG., Target specific virtual screening: optimization of an estrogen receptor screening platform., Journal of Medicinal Chemistry, 50, (22), 2007, p5301-5310 |
|
Contact: bbutler@tcd.ie. |
Last updated: Oct 25 2011.
|