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Publications

COMPARATIVE IMMUNOLOGY GROUP

Prof Cliona O’Farrelly

    Key Publications:

  1. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. O'Connell J, Lynch L, Cawood TJ, Kwasnik A, Nolan N, Geoghegan J, McCormick A, O'Farrelly C, O'Shea D. PLoS One. 2010 Apr 1;5(4):e9997. PMID : 20376319 [PubMed - in process]


  2. Nemeth E, Baird AW, O'Farrelly C. Microanatomy of the liver immune system. Semin Immunopathol. 2009 Jul 29. [Epub ahead of print]


  3. Lynch, L, O'Shea, D, Winter, D, Geoghegan, J, Doherty, D and O'Farrelly, C (2009). Invariant NKT cells and CD1d-positive cells amass in human omentum and are depleted in patients with cancer and obesity. Eur. J. Immunol. 2009 Jul;39(7):1893-901.


  4. Hepatic Interleukin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development L.Golden-Mason, A.Kelly, J.Hegarty*, C.O'Farrelly*. Clin Exp Immunol 2004 Oct;138(1):94-101 PMID 15373910.


  5. Adult human liver contains CD8pos T cells with naïve phenotype but is not a site for conventional ??-T cell development. L. Golden-Mason , D.C. Doeuk, R.A. Koup, J. Kelly, J.E. Hegarty*, C. O'Farrelly* J Immunol 2004 May 15;172(10):5980-5 PMID 15128780.


  6. Expression of interleukin 7 (IL-7) mRNA and protein in the normal adult human liver: implications for extrathymic T cell development. L. Golden-Mason, A. Kelly, O. Traynor, G. McEntee, J. Kelly, J. Hegarty*, C. O'Farrelly*. Cytokine 2001 ;14:143-151. PMID 11396992.


  7. Differential expression of lymphoid and myeloid markers on differentiating hematopoietic stem cells in normal and tumor bearing adult human liver. L. Golden-Mason, M. Curry, N. Nolan, O. Traynor, G. McEntee, J. Kelly, J. Hegarty*, C. O'Farrelly*. Hepatology 2000 ;31:1251-1256. PMID 10827150.


  8. High and low affinity peptide ligands have distinct effects on the development of mucosal CD8?? and CD8?? T lymphocytes. C.P. Levelt, Y.P. de Jong, E. Mizoguchi, A.K. Bhan, C. O'Farrelly, S. Tonegawa, C. Terhorst, S.J. Simpson . Proc Natl Acad Sci 1999 ;96:5628-5633. PMID 10318935.


  9. The human liver contains multiple populations of NK cells, T cells and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2 and Th0 cytokine secretion patterns. D. Doherty, S. Norris, L. Madrigal-Estebas, G. McEntee, O. Traynor, J. Hegarty, C. O'Farrelly. J Immunol 1999 ;163:2314-2321. PMID 10438977.


  10. Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include V?24-J?Q and ?? T cell receptor bearing cells. S. Norris, D. Doherty, C. Collins, G. McEntee, O. Traynor, J. Hegarty, C. O'Farrelly. Hum Immunol 1999 ;60:20-31. PMID 9952024.


  11. In vitro evidence for the presence of hematopoietic stem cells in the adult human liver . O.M. Crosbie, M. Reynolds, G. McEntee, O. Traynor, J. Hegarty, C. O'Farrelly. Hepatology 1999 ;29:1193-1198. PMID 10094964.


  12. Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes. S. Norris, C. Collins, D. Doherty, F. Smith, G. McEntee, O. Traynor, N. Nolan, J. Hegarty, C. O'Farrelly. J Hepatol 1998 ;28:84-90. PMID 9537869.


  13. RAG 1, RAG 2 and Pre TCR ? chain expression by adult human hepatic T cells: evidence of extrathymic T cell maturation. C. Collins, S. Norris, G. McEntee, O. Traynor, L. Bruno, H. van Boehmer, J. Hegarty, C. O'Farrelly. Eur J Immunol 1996 ;26:3114-3118. PMID 8977312.


  14. Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: evidence of activation? M. Abuzakouk, D. Kelleher, C. Feighery, C. O'Farrelly . Gut 1996 ;39:396-400. PMID 8949644.


  15. Collagenase and dispase enzymes disrupt lymphocyte surface molecules. M. Abuzakouk, C. Feighery, C. O'Farrelly. J Immunol Methods 1996 ;194:211-216. PMID 8765174.


  16. RAG-1 and RAG-2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation. S. Lynch, D. Kelleher, R. McManus, C. O'Farrelly. Eur J Immunol 1995 ;25:1143-1147. PMID 7774617.


  17. Adhesion molecules utilized in binding of intraepithelial lymphocytes to human enterocytes. D. Kelleher, A. Murphy, S. Lynch, C. O'Farrelly. Eur J Immunol 1994 ;24:1013-1016. PMID 7908632


  18. Flow cytometric analysis of intraepithelial lymphocytes from human small intestinal biopsies reveals populations of CD4+CD8+ and CD8??+cells. S. Lynch, D. Kelleher, C. Feighery, D. Weir, C. O'Farrelly. Eur J Gastroenterol Hepatol 1993 ;5:907-912.

    19.  * These authors contributed equally to the direction of this study

    HCV Publications:

  19. Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection. Dring MM, Morrison MH, McSharry BP, Guinan KJ, Hagan R; Irish HCV Research Consortium, O'Farrelly C, Gardiner CM. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5736-41. Epub 2011 Mar 14. PMID: 21402922


  20. Risk factors for the development of depression in patients with hepatitis C taking interferon-a. Smith KJ, Norris S, O'Farrelly C, O'Mara SM. Neuropsychiatr Dis Treat. 2011;7:275-92. Epub 2011 May 15. PMID: 21654873 [PubMed - in process]


  21. Petrovic D, Stamataki Z, Dempsey E, Golden-Mason L, Freeley M, Doherty D, Prichard D, Keogh C, Conroy J, Mitchell S, Volkov Y, McKeating JA, O'Farrelly C, Kelleher D, Long A. Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion. Hepatology. 2011 Mar 30. doi: 10.1002/hep.24327. [Epub ahead of print]


  22. Interferon-a suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist. Tajuddin T, Ryan EJ, Norris S, Hegarty JE, O'Farrelly C. J Gastroenterol Hepatol. 2010 Dec;25(12):1883-90.


  23. Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection. Ryan EJ, Dring M, Ryan CM, McNulty C, Stevenson NJ, Lawless MW, Crowe J, Nolan N, Hegarty JE, O'Farrelly C. Hum Immunol. 2010 Aug;71(8):829-32. Epub 2010 May 12.


  24. Effect of chronic hepatitis C virus infection on bone disease in postmenopausal women. Nanda KS , Ryan EJ, Murray BF, Brady JJ, McKenna MJ, Nolan N, O'Farrelly C, Hegarty JE. Clin Gastroenterol Hepatol. 2009 Aug;7(8):894-9. Epub 2009 Jan 24.


  25. Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta. Rowan AG, Fletcher JM, Ryan EJ, Moran B, Hegarty JE, O'Farrelly C, Mills KH. J Immunol. 2008 Oct 1;181(7):4485-94.


  26. Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure. Golden-Mason L, Madrigal-Estebas L, McGrath E, Conroy MJ, Ryan EJ, Hegarty JE, O'Farrelly C, Doherty DG. Gut. 2008 Aug;57(8):1121-8. Epub 2008 Mar 27.


  27. Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence. Rosen HR, Doherty DG, Madrigal-Estebas L, O'Farrelly C, Golden-Mason L. Liver Transpl. 2008 Jan;14(1):31-40.


  28. Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection. Golden-Mason L, Castelblanco N, O'Farrelly C , Rosen HR. J Virol . 2007 Sep;81(17):9292-8. Epub 2007 Jun 6.


  29. The impact of inherited prothrombotic risk factors on individuals chronically infected with hepatitis C virus from a single source. Goulding C, O'Brien C, Egan H, Hegarty JE, McDonald G, O'Farrelly C, White B, Kelleher D, Norris S. J Viral Hepat . 2007 Apr;14(4):255-9.


  30. The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration. Volkov Y, Long A, Freeley M, Golden-Mason L, O'Farrelly C, Murphy A, Kelleher D. Gastroenterology. 2006 Feb;130(2):482-92.


  31. Reconstitution of hepatitis C virus-specific T-cellmediated immunity after liver transplantation. Weston SJ, Leistikow RL, Reddy KR, Torres M, Wertheimer AM, Lewinsohn DM, Chou S, Davey MP, Corless C, O'Farrelly C, Nelson DR, Rosen HR. Hepatology. 2005 Jan;41(1):72-81.


  32. Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver. Curry MP, Golden-Mason L, Doherty DG, Deignan T, Norris S, Duffy M, Nolan N, Hall W, Hegarty JE, O'Farrelly C. J Hepatol. 2003 May;38(5):642-50.


  33. Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection. Deignan T, Curry MP, Doherty DG, Golden-Mason L, Volkov Y, Norris S, Nolan N, Traynor O, McEntee G, Hegarty JE, O'Farrelly C. J Hepatol. 2002 Jul;37(1):101-8.


  34. Expansion of peripheral blood CD5+ B cells is associated with mild disease in chronic hepatitis C virus infection. Curry MP, Golden-Mason L, Nolan N, Parfrey NA, Hegarty JE, O'Farrelly C. J Hepatol. 2000 Jan;32(1):121-5.

    35. Avian Immune System Publications:

  35. Global gene expression analysis of chicken caecal response to Campylobacter jejuni . Shaughnessy R, Meade K, McGivney B, Allan B, O'Farrelly C, Veterinary Immunology and Immunopathology 142 (2011) 64– 71


  36. The differential evolutionary dynamics of avian cytokine and TLR gene classes. Downing T, Lloyd AT, O'Farrelly C, Bradley DG. J Immunol. 2010 Jun 15;184(12):6993-7000. Epub 2010 May 14. PMID : 20483729


  37. Evidence of the adaptive evolution of immune genes in chicken. Downing T, Cormican P, O'Farrelly C, Bradley DG, Lloyd AT. BMC Res Notes. 2009 Dec 15;2:254. PMID : 20003477


  38. Variation in chicken populations may affect the enzymatic activity of lysozyme. Downing T, O'Farrelly C, Bhuiyan AK, Silva P, Naqvi AN, Sanfo R, Sow RS, Podisi B, Hanotte O, Bradley DG. Anim Genet. 2010 Apr 1;41(2):213-7 Epub 2009 Oct 21. PMID : 19845599


  39. Shaughnessy RG, Meade KG, Cahalane S, Allan B, Reiman C, Callanan JJ, O'Farrelly C. Innate immune gene expression differentiates the early avian intestinal response between Salmonella and Campylobacter. Vet Immunol Immunopathol. 2009 Jun 21. [Epub ahead of print]


  40. Cormican P, Lloyd AT, Downing T, Connell SJ, Bradley D, O'Farrelly C. The avian Toll-Like receptor pathway--subtle differences amidst general conformity. Dev Comp Immunol. 2009 Sep;33(9):967-73. Epub 2009 Apr 24. PMID: 19539094.


  41. Downing T, Lynn DJ, Connell S, Lloyd AT, Bhuiyan AK , Silva P, Naqvi AN, Sanfo R, Sow RS, Podisi B, Hanotte O, O'Farrelly C, Bradley DG. Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus. BMC Evol Biol. 2009 Jun 15;9(1):136. [Epub ahead of print] PMID: 19527513


  42. Downing T, Lynn DJ, Connell S, Lloyd AT, Bhuiyan AK, Silva P, Naqvi AN, Sanfo R, Sow RS, Podisi B, O'Farrelly C, Hanotte O, Bradley DG Contrasting evolution of diversity at two disease-associated chicken genes. Immunogenetics. 2009 Apr;61(4):303-14. Epub 2009 Feb 27. Erratum in: Immunogenetics. 2009 May;61(5):421-2. PMID: 19247647


  43. Meade KG, Narciandi F, Cahalane S, Reiman C, Allan B, O'Farrelly C. Comparative in vivo infection models yield insights on early host immune response to Campylobacter in chickens. Immunogenetics. 2009 Feb;61(2):101-10. Epub 2008 Dec 12. PMID: 19082824


  44. Meade KG, Higgs R, Lloyd AT, Giles S, O'Farrelly C. Differential antimicrobial peptide gene expression patterns during early chicken embryological development. Dev Comp Immunol. 2009 Apr;33(4):516-24. Epub 2008 Nov 11. PMID: 19007808


  45. Induction of a novel chicken TLR Following Salmonella enterica serovar typhimurium infection R. Higgs, P. Cormican, S. Cahalane, B. Allan, A.T. Lloyd, K. Meade, J. Tharappel, D. Lynn, L.A. Babiuk, C. O'Farrelly Infection & Immunity 2006 Mar;74(3):1692-8. PMID 16495540.


  46. The synthetic form of a novel chicken b-defensin identified in silico is predominantly active against intestinal pathogens R. Higgs, D.J. Lynn, S. Gaines, J. McMahon, J. Tierney, J. Tharappel, A.T. Lloyd, G. Mulcahy, C. O'Farrelly Immunogenetics 2005 Apr;57(1-2):90-8; PMID 15744537.


  47. Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken D.J. Lynn, R. Higgs, S. Gaines, J. Tierney, T. James, A.T. Lloyd, M.A. Fares, G. Mulcahy, C. O'Farrelly. Immunogenetics 2004 Jun:56(3):170-7 PMID 15148642.


  48. In Silico identification of components of the Toll-like receptor (TLR) signalling pathway in clustered chicken ESTs. D.Lynn, A.Lloyd, C.O'Farrelly Vet Immunol Immunopathol 2003; 93:177-184 PMID 12814703.


  49. Inhibition of S. mutans growth by hen egg derived fatty acids. D. Brady, N. Lowe, S. Gaines L. Fenelon, J. McPartlin, C. O'Farrelly J Food Sci 2003 Vol.68(4)1433-1437.


  50. A lipoprotein derived antimicrobial factor from hen egg yolk is active against Streptococcus species. D. Brady, S. Gaines, L. Fenelon, J. Mc Partlin, C. O'Farrelly. J Food Sci 2002;67:3096-3103.


  51. Hen egg yolk prevents bacterial adherence: a novel function for a familiar food . T.Deignan, A. Alwan, L. Malone, J. Kelly, C. O'Farrelly. J Food Sci 2001 ;66:158-161.


  52. Comparative analysis of methods of purification of egg yolk immunoglobin (IgY). T. Deignan, J. Kelly, A. Alwan, C. O'Farrelly. Food Agric Immunol 2000;12:77-85.


  53. Oral ingestion of egg yolk immunoglobulin from hens immunized with an enterotoxigenic Escherichia coli strain prevents diarrhea in rabbits challenged with the same strain. C. O'Farrelly, D. Branton, C. Wanke. Infect Immun 1992; 60:2593-2597. PMID 1612729.

Further information on the Comparative Immunology Group

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Last updated: Sep 09 2011.
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