INFLAMMATION RESEARCH
Prof Luke O'Neill
Luke O'Neill, PhD
Phone: + 353-1-896-2439
Fax: + 353 - 1 - 6772400
Email: laoneill@tcd.ie
Location: Room 4.33, Biomedical Sciences Institute |
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Research Interests
The major focus of the group is to provide a molecular understanding of innate immunity and inflammation. We are interested in receptors involved in innate immunity, such as Toll-like receptors (TLRs) and Nod-like receptors (NLRs – including Nlrp3), and also signals activated, including NF-kappaB, IRF family transcription factors and MAP kinases. The role played by this system in inflammatory diseases is also under investigation. We have several projects underway including –
- Role of the adapter Mal in the epithelial barrier in the gut
- Control of TLRs and NLRs by microRNAs
- Role of Nlrp3 in Type 2 diabetes
- Novel proteins in the TLR and NLR systems
- The role of Btk in TLR signalling
- The control of trafficking of TLR4
- Genetic variation in innate immune genes and inflammatory diseases
- Role of IL-36 in inflammation
Research Personnel
Post-doctoral fellows:
Sinead Corr PhD
Emma Creagh PhD
Sarah Doyle PhD
Claire McCoy PhD
Seth Masters PhD
Jennifer Dowling PhD
Elaine Kenny PhD
Anne McGettrick PhD
Eva Palsson McDermott PhD
Gillian Tannahill PhD
Graduate Students:
Andrea Scharfe MB BS
Dympna Connolly BA (Mod)
Rebecca Coll BA (Mod)
Sue Quinn BA (Mod)
Mustafa Alam BSc
Paulina Wochal MSc
Nick Bernard BSc
Research Support:
Kathy Banahan BSc
Cait Donoghue BSc
Emer Murphy MSc
Financial Support
Science Foundation Ireland, Health Research Board, Enterprise Ireland, European Commission, Wellcome Trust
Major Collaborators
Kate Fitzgerald (UMass, USA)
Nick Gay (University of Cambridge)
Doug Golenbock (UMass, USA)
Jorge Camaano (University of Birmingham)
Phil Auron (Duquesne University USA)
Bryan Williams (Monash University, Australia)
Youhai Chen (University of Pennsylvania)
Recent Publications by the Inflammation Research Group
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