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Professor Luke O'Neill

Inflammation Research


L. O'Neill photo

Luke O'Neill, PhD
Phone: + 353-1-896-2439
Fax: + 353 - 1 - 6772400
Email: laoneill@tcd.ie
Location: Room 4.33, Trinity Biomedical Sciences Institute


RESEARCH INTERESTS


View audio/video clip of Prof O'Neill talking about his research (mp4, 9.5MB)

The major focus of the group is to provide a molecular understanding of innate immunity and inflammation. We are interested in receptors involved in innate immunity, such as Toll-like receptors (TLRs) and Nod-like receptors (NLRs – including Nlrp3), and also signals activated. The role played by this system in inflammatory diseases is also under investigation. We have several projects underway including –

  • Control of TLRs and NLRs by microRNAs
  • Role of Nlrp3 in Type 2 diabetes
  • Novel proteins in the TLR and NLR systems
  • Inhibitors of Nlrp3
  • Role of metabolism in innate immunity
  • Circadian control of innate immunity

RESEARCH PERSONNEL

Post-doctoral fellows:
Rebecca Coll PhD
Sinead Corr PhD
Annie Curtis PhD
Raqual Domingo-Fernandes PhD
Caio Fagundes PhD
Claire McCoy PhD
Anne McGettrick PhD
Eva Palsson McDermott PhD
Gillian Tannahill PhD

Graduate Students:
Sue Quinn BA (Mod)
Mustafa Alam BSc
Paulina Wochal MSc
Nick Bernard BSc
Mirjam Van Den Bosch MSc
Moritz Haneklaus MSc
Evanna Mills BA (Mod)
Beth Kelly BA (Mod)
Silvia Pena BA (Mod)
Danny Johnston  BA (Mod)
Sarah Jany BA (Mod)

Research Support:
Kathy Banahan BSc
Cait Donoghue BSc

FINANCIAL SUPPORT

Science Foundation Ireland, Health Research Board, Enterprise Ireland, European Commission, Wellcome Trust

MAJOR COLLABORATORS

Kate Fitzgerald (UMass, USA)
Nick Gay (University of Cambridge)
Doug Golenbock (UMass, USA)
Ramnik Xavier (Mass General)
Mihai Netea (University of Njimegan)

PUBLICATIONS

Publications

 


Last updated 12 May 2014 bbutler@tcd.ie (Email).