Prof Keith Tipton
Neurochemistry, Enzymology and Systems Biology
Professor Keith Tipton
Phone: + 353-1-896 1802
Fax: + 353 -1-6772400
Location: Room 5.53, Trinity Biomedical Sciences Institute
- Enzyme behaviour, enzyme inhibition and enzymes with alternative functions.
- Systems biology.
- Enzymes and metabolic systems.
1. Enzyme Behaviour
(i) Mechanisms through which the copper-containing amine oxidase (semicarbazide-sensitive amine oxidase; EC 184.108.40.206) also functions as a vascular-adhesion protein and modulates cellular glucose uptake.
(ii) Mechanisms of the complex behaviour shown by the oxidase reaction catalysed by peroxidase (EC 220.127.116.11).
(iii) The multiple functions of ceruloplasmin (ferroxidase; EC 18.104.22.168).
(iv) The behaviour and applications of suicide inhibitors and suicide substrates.
2. Systems Biology
Systems biology is the application of computational approaches to the understanding of the normal and dysfunctional behaviour of cellular systems.
Current projects include:
(i) Pathway tracing and metabolite connections.
(ii) Regulation of glucose transport in adipocytes and metabolism in normal and diabetic states.
(iii) Regulatory behaviour of branching processes.
(iv) Function and dysfunction of the aminergic nerve terminal.
(v) Complex dynamics and their biological significance.
3. Enzyme Bioinformatics
We are responsible for curation of the International Union of Biochemistry and Molecular Biology's (IUBMB's) Enzyme List. This is a functional classification system in which novel enzymes are classified according to the reactions they catalyse, with each new enzyme being assigned an EC number. The work also involves updating entries for previously classified enzymes in the light of current knowledge. As the EC system is used extensively in many bioinformatics efforts, our group collaborates with many of the major world-wide bioinformatics centres, including the European Bioinformatics Institute, Cambridge (IntEnz), Kyoto University Bioinformatics Center (KEGG), University of Geneva (ExPASy and SWISS-PROT databases), University of Cologne (BRENDA database), University of Missouri at Columbia (KLOTHO database) as well as with IUBMB and IUPAC in this work.
International Union of Biochemistry and Molecular Biology (IUBMB)
- Enzyme Nomenclature (NC-IUBMB) <http://www.enzyme-database.org>
- Form for submitting details of a new enzyme <http://www.enzyme-database.org/newform.php>
- Form for submitting details of an error/update to an existing enzyme entry <http://www.enzyme-database.org/updateform.php>
- IUBMB-Nicholson Metabolic Pathway Minimaps: <http://www.iubmb-nicholson.org/minimaps.html> and animated representations Animaps: <http://www.iubmb-nicholson.org/animaps.html>
MAJOR ACADEMIC COLLABORATORS:
Dept. of Biochemistry, Autonomous University of Barcelona, Spain (Prof. Mercedes Unzeta)
Dept of Biochemistry, University of Cambridge, UK (Dr. Hal Dixon)
Dept of Biochemistry, University of Cologne, Germany (Prof. Dietmar Schomburg)
Dept of Biochemistry, University of Louvain-la-Neuve, Belgium (Prof. Robert Chrichton & Dr. Roberta Ward)
Dept. of Computer Science, University of Missouri, USA (Prof. Toni Kazic)
Dept of Pharmacology, University of Florence, Italy (Profs. Laura Della Corte & Laura Raimondi)
Dept of Pharmacology, University of Siena, Italy (Profs. Mitri Palmi, Giampietro Sgaragli & Massimo Valoti)
Dept of Pharmacology, University of Oxford, UK (Dr. J. Paul Bolam)
Dept of Pharmacology, Technion, Haifa, Israel (Prof. Moussa Youdin)
Dept of Pharmacology, University of Uppsala, Sweden (Prof. Lars Oreland)
European Bioinformatics Institute, Cambridge, UK (Dr. Rolf Apweiler)
Queen Mary University of London, UK (Dr. G.P. Moss)
Psychiatric Research Division, University of Saskatoon, Canada (Prof. Peter Yu)
Dublin Dental School (Dr. Michael O’Sullivan)