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Dr Anne Molloy

Vitamins in one-carbon metabolism


Dr Anne M Molloy, Ph.D., M.A., P.G. Dip. Statistics, FTCD
Associate Professor, (School of Medicine)
Phone: + 353-1-896-1616
Fax: + 353 - 1 - 6772400
Email: amolloy@tcd.ie
Location: Room 5.08, Trinity Biomedical Sciences Institute

Main Collaborators:

Dr James Mills, Eunice Shriver NICHD, National Institutes of Health, USA
http://www.nichd.nih.gov/news/profiles/researchers/mills/Pages/video3.aspx

Dr Lawrence Brody, National Human Genome Research Institute, National Institutes of Health, USA 
http://www.genome.gov/page.cfm?pageID=10000731

Professor Helene McNulty and colleagues, NICHE, University of Ulster, Coleraine, Northern Ireland
http://biomed.science.ulster.ac.uk/niche/-Folate-and-related-B-vitamins-in-.html

Joint Irish Nutrigenomics Organisation (JINGO Consortium)
http://www.ucd.ie/jingo/

Research Interests:

  • The role of one-carbon metabolism in pregnancy, incorporating (1) the cause of folate responsive neural tube defects, in particular the nutritional, biochemical and genetic parameters associated with these disorders; (2) the effects of inadequate folate or vitamin B12 nutrition on complications of pregnancy and adverse pregnancy outcomes; (3) the role of folate and vitamin B12 in other congenital disorders including orofacial clefts and congenital heart disease.
  • Links between folate, vitamin B12 and other nutritional determinants of one-carbon metabolism in relation to risk of chronic disease in the elderly including cognition and cardiovascular disease.  Genetic and epigenetic influences on this risk.
  • The development and application of new techniques in the analysis of folate and vitamin B12 related metabolites. Evaluation of the relative utility of such markers in clinical practice.
  • The uptake and utilisation of folates in normal and deficient states; the effect of common genetic variation in folate related enzymes on folate status and metabolism.

PUBLICATIONS

Publications


Last updated 24 October 2017 bbutler@tcd.ie (Email).