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Dr Anne Molloy

Vitamins in one-carbon metabolism

Dr Anne M Molloy, Ph.D., M.A., P.G. Dip. Statistics, FTCD
Associate Professor, (School of Medicine)
Phone: + 353-1-896-1616
Fax: + 353 - 1 - 6772400
Location: Room 5.08, Trinity Biomedical Sciences Institute

Main Collaborators:

Dr James Mills, Eunice Shriver NICHD, National Institutes of Health, USA

Dr Lawrence Brody, National Human Genome Research Institute, National Institutes of Health, USA

Professor Helene McNulty and colleagues, NICHE, University of Ulster, Coleraine, Northern Ireland

Joint Irish Nutrigenomics Organisation (JINGO Consortium)

Research Interests:

  • The role of one-carbon metabolism in pregnancy, incorporating (1) the cause of folate responsive neural tube defects, in particular the nutritional, biochemical and genetic parameters associated with these disorders; (2) the effects of inadequate folate or vitamin B12 nutrition on complications of pregnancy and adverse pregnancy outcomes; (3) the role of folate and vitamin B12 in other congenital disorders including orofacial clefts and congenital heart disease.
  • Links between folate, vitamin B12 and other nutritional determinants of one-carbon metabolism in relation to risk of chronic disease in the elderly including cognition and cardiovascular disease.  Genetic and epigenetic influences on this risk.
  • The development and application of new techniques in the analysis of folate and vitamin B12 related metabolites. Evaluation of the relative utility of such markers in clinical practice.
  • The uptake and utilisation of folates in normal and deficient states; the effect of common genetic variation in folate related enzymes on folate status and metabolism.



Last updated 24 October 2017 (Email).