VITAMINS IN ONE-CARBON METABOLISM
Dr Anne Molloy
Anne M Molloy, B.Sc, Ph.D, Dip. Statistics,
Research Senior Lecturer
Department of Clinical Medicine
Phone: + 353-1-896-1616
Fax: + 353 - 1 - 6772400
Email: amolloy@tcd.ie
Location: Room 6.09, Biomedical Sciences Institute |
 |
In collaboration with:
Professor John Scott, School of Biochemistry and Immunology.
Dr James L Mills, National Institutes for Child Health and Development, Bethesda, USA
Dr Larry Brody, National Human Genome Research Institute, Bethesda, USA
Dr Peadar Kirke, Health Research Board, Dublin, Ireland
Dr Helene McNulty, University of Ulster at Coleraine, Northern Ireland
Dr Sean Daly, Coombe Women's Hospital, Dublin 8
Research Interests:
- The role of folate in pregnancy: This incorporates two principal areas; (1) the cause of folate responsive neural tube defects, in particular the nutritional, biochemical and genetic parameters associated with these disorders and (2) the effects of inadequate folate nutrition on complications of pregnancy and adverse pregnancy outcomes. The role of folate in other congenital disorders including oro-facial clefts and congenital heart disease is an extension of this area of interest.
- The uptake and utilisation of folates in normal and deficient states: A particular area of interest is the effect of genetic variants in folate related enzymes on folate status and metabolism. Research methods include cell culture studies and studies on nutritional status in human subjects, stratified according to a genotype of interest.
- The development and application of new techniques in the analysis of folates and folate related metabolites including HPLC methods, amino acid analysis, radioisotope methods, microbiological assays and cell culture technology.
- Links between folate and vitamin B12; specifically, the influence of folate and vitamin B12 status on methylation reactions and s-adenosylmethionine metabolism. This included investigations into the aetiology of "subacute combined degeneration of the cord", the neurological lesion associated with vitamin Bl2 deficiency, the role of methylation in vitamin B12 neuropathy and the myelopathy of AIDS.
Recent Publications by Dr Molloy
[Top of Page] |
