Publications

PUBLICATIONS

1. Oliveira T, Panjikar S, Carrigan JB, Hamza M, Engel PC, Khan AR (2011) Crystal Structure of NAD-dependent Peptoniphilus asaccharolyticus Glutamate Dehydrogenase in the Apo Form Reveals Determinants of Cofactor Specificity. Journal of Structural Biology, in the press.

2. Jin Y, Sultana A, Gandhi P, Franklin E, Hammamoto S, Khan AR , Munson M, Schekman R, Weisman L (2011) Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex. Developmental Cell, in the press.

3. Sultana A, Jin Y, Dregger C, Franklin E, Weisman L, Khan AR (2011) The Activation Cycle of Rab GTPase Ypt32 Reveals Structural Determinants of Effector Recruitment and GDI Binding. FEBS Lett, in the press.

4. Oda S, Franklin E, Khan AR (2011) Poxvirus A46 proteinbinds to TIR domain-containing Mal/TIRAP via an a -helical sub-domain. Molecular Immunology 48 : 2144-2150.

5. Fernandes H, Franklin E, Khan AR (2011) Crystallization of an engineered RUN domain of Rab6-interacting protein 1/DENND5. Acta Cryst F67 : 556-560.

6. Oliveira TF, Franklin E, Alfonso JP, Khan AR , Oldham NJ, Pereira IAC, Archer M (2011) Structural insights into dissimilatory sulfite reductases: structure of desulforubidin from Desulfomicrobium norvegicum. Frontiers in Micribiology 2 : 1-12

7. Oliveira TF, Carrigan JB, Hamza MA, Sharkey MA,Engel PC, Khan AR (2010) Crystallization and preliminary structural analyses of glutamate dehydrogenase from Peptoniphilus asaccharolyticus. Acta Crystallogr Sect F 66: 523-526

8. Nagle PS, Quinn SJ, Kelly JM, O'Donovan DH, Khan AR , Rodriguez F, Nguyen B, Wilson WD, Rozas I (2010) Understanding the DNA binding of novel non-symmetrical guanidinium/2-aminoimidazolinium derivatives. Org Biomol Chem 8: 5558-5567

9. Crowley PB, Matias PM, Khan AR , Roessle M & Svergun DI (2009) Metal-Mediated Self-Assembly of a b-Sandwich Protein. Chemistry – A European Journal, Chemistry. 2009 Nov 23;15(46):12672-80.

10. Fernandes H, Franklin E, Recacha R, Houdusse A, Goud B & Khan AR (2009) Structural aspects of Rab6-Effector complexes. Biochem Soc Trans 37(Pt 5) : 1037-1041.

11. Recacha R, Boulet A, Jollivet F, Monier S, Houdusse A, Goud B & Khan AR (2009) Structural basis for recruitment of Rab6-Interacting Protein 1 to Golgi via a RUN domain. Structure 17 :21-30.

12. Kalverda AP, Thompson GS, Vogel A, Schröder M, Bowie AG, Khan AR & Homans SW (2009) Poxvirus K7 protein adopts a Bcl-2 fold: Biochemical mapping of its interactions with human DEAD box RNA helicase DDX3. J Mol Biol 385 : 843-853.

13. Horgan CP, Oleksy1 A, Alexander V. Zhdanov AV, Lall PY, Ian J. White, Khan AR, Futter CE, McCaffrey JG & McCaffrey MW (2007) Rab11-FIP3 is critical for the structural integrity of the endosomal-recycling compartment. Traffic 8: 414-430.

14. Khor CC, [7 authors], Kyrieleis O, Khan AR, [20 authors], O'Neill LA & Hill AVS (2007) A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis. Nature Gen 39: 523-528.

15. Jagoe WN, Lindsay AJ, Read RJ, McCoy AJ, McCaffrey MW & Khan AR (2006) Crystal structure of Rab11 in complex with Rab11 Family Interacting Protein 2. Structure 14: 1273-1283.

16. Jagoe WN, Jackson SR, Lindsay AJ, McCaffrey MW & Khan AR (2006) Purification, crystallization and preliminary X-ray diffraction studies of Rab11 in complex with Rab11-FIP2 Acta Cryst. (2006). F62, 692-694.

17. Chen M, Stafford W, Diedrich G, Khan AR & Bouvier M (2002) A characterization of the lumenal region of human tapasin reveals the presence of two structural domains. Biochemistry 41: 14539-14545.

18. Khan AR, Baker BM, Ghosh P, Biddison WE & Wiley DC (2000) The structure and stability of an HLA-A*0201/octameric Tax peptide with an empty conserved peptide N-terminal binding site. Journal of Immunology 164: 6398-6405

19. Khan AR, Khazanovich-Bernstein N, Bergmann EM & James MNG (1999) Structural aspects of the activation pathways of aspartic protease zymogens and viral 3C protease zymogens. Proc Natl Acad Sci USA 96: 10968-10975.

20. Khan AR, Parrish JC, Fraser ME, Smith WW, Bartlett PA & James MNG (1998) Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes. Biochemistry 37: 16839-16845.

21. Khan AR & James MNG (1998) Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes. Protein Science 7: 815-836.

22. Mark BL, Wasney GA, Salo T, Khan AR, Cao Z, Robbins PW, James MNG & Triggs-Laine BL (1998) Structural and functional characterization of Streptomyces plicatus b -N-acetylhexosaminidase by comparative molecular modelling and site-directed mutagenesis. Journal of Biological Chemistry 273: 19618-19624.

23. Khan AR, Cherney MM, Tarasova NI & James MNG (1998) Crystallographic studies of an activation intermediate of human gastricsin. Adv Exp Med Biol 436: 265-270.

24. Khan AR, Cherney MM, Tarasova NI & James MNG (1997) Structural characterization of activation ‘intermediate 2’ on the pathway to human gastricsin. Nature Structural Biology 4: 1010-1015.

25. Khan AR, Johnson KA, Braam J & James MNG (1997) Comparative molecular modelling of the three-dimensional structure of calmodulin-related TCH2 protein from Arabidopsis. Proteins: Structure, Function and Genetics 27: 144-153.

26. Khan AR, Williams KA, Boggs JM & Deber CM (1995) Accessibility and dynamics of viable Cys mutants of phage IKe and M13 major coat proteins. Biochemistry 34: 12388-12397.

27. Williams KA, Glibowicka M, Li Z, Li H, Khan AR, Chen YM, Wang J, Marvin DA & Deber CM (1995) Role of small residues in filamentous phage packing. Journal of Molecular Biology 252: 6-14.

28. Khan AR & Deber CM. (1995) An engineered disulfide bridge in the transmembrane region of phage M13 coat protein stabilizes the a -helical dimer. Biochem Bioph Res Comm 206: 230-237.

29. Deber CM, Khan AR, Li Z, Joensson C, Glibowicka M & Wang J (1993) Val to Ala mutations selectively alter helix-helix packing in the transmembrane segment of phage M13 coat protein. Proc Natl Acad Sci USA 90: 11648-11652.

Trinity College Dublin

Publications