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picture of crystal
X-Ray Crystallography Laboratory logo TCD crest

Welcome to the Protein Crystallography Group homepage!

Our group was established in 2004 with support from the Higher Education Authority (through their PRTLI3 initiative), as well as a grant from Science Foundation Ireland. We are dedicated to exploring the molecular basis for biological processes in living cells. The main technique employed in our laboratory is X-ray diffraction, which allows visualization of the three-dimensional architecture of macromolecules. An introduction to protein crystallization and X-ray diffraction is provided in a Brief Introduction to Protein Crystallography.

There are two main projects underway in our laboratory. The first is a structural study of Rabs with their effector proteins, and the mechanism by which these complexes regulate vesicle trafficking. A second major initiative involves structural studies of Toll receptor signaling pathways, which are essential for innate immunity against bacteria and viruses. Please click on research projects to learn more about the work in our laboratory.

The overall research goal is to provide insight into the specificity of signaling complexes, and how they lead to changes in cellular activity. To address these problems, our lab is fully equipped for protein expression, purification, crystallization and structure determination. For details on the equipment and resources available in our group, please visit the laboratory resources page.

Contact: bbutler@tcd.ie.
Last updated: Aug 04 2006.