Main Area of Interest
By way of background, I hold a BSc in Applied Chemistry a PhD in Medicinal Organic Chemistry, both from Dublin City University. I spent three years as a post-doctoral researcher in the School of Pharmacy, TCD working on the computer-aided rational design of novel anti-estrogens for use as breast cancer chemotherapeutics. In 2001, I left academia to take a post as Senior Scientist in the Applied Design group of De Novo Pharmaceuticals in Cambridge, UK, where I worked on many therapeutic projects using computational drug design strategies and techniques and headed the company's ligand-based design discovery program. I subsequently returned to Ireland in 2004 to join the then Department of Biochemistry, now School of Biochemistry and Immunology here in TCD, where as a Senior Lecturer I am appointed as Hitachi Lecturer in Advanced Computing. In 2005 I was appointed as Associate Dean of Research for Trinity. Currently I am acting as Dean of Research for Trinity College.I enjoy the challenges of rational drug design, and the mandate for the group is validate, validate, validate, - there's no such thing as an active in silico hit. To that end I make sure that all members of the MDG spend some time away from the monitors, in the wetlab, assaying and testing, working towards proving the concept that rational design augments the discovery process.
History:
B.Sc. (DCU)PhD (DCU)
C. Chem., MRSC
Molecular Design Group Founder (TCD 2004)
Hitachi Lecturer in Advanced Computing (TCD)
Associate Dean of Research (TCD 2005-2007)
Dean of Research (TCD 2007-Current)
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