Publications

Total number of publications: 62

Total citations (Scopus): 697

h index (Scopus): 14

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2012

Coleman, M.M., Finlay, C.M., Moran, B., Keane, J., Dunne, P.J., Mills, K.H.
The immunoregulatory role of CD4 FoxP3 CD25 regulatory T cells in lungs of mice infected with Bordetella pertussis.
FEMS Immunology and Medical Microbiology 64: 413-424. (2012)

Cunningham, C., Mills, E., Mielke, L.A., O’Farrell, L.K., Lavelle, E., Mori, A., McCarthy, G.M., Mills, K.H.G., Dunne, A. Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and danger-associated molecules via activation of Syk and PI3 kinase.
Clinical Immunology 144(3): 228-236. (2012). Citations: 1

Doyle, S.L., Campbell, M., Ozaki, E., Salomon, R.G., Mori, A., Kenna, P.F., Farrar, G.J., Kiang, A.S., Humphries, M.M., Lavelle, E.C., O'Neill, L.A., Hollyfield, J.G., Humphries, P.
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components.
Nature Medicine 18(5): 791-798. (2012) Citations: 7

Haneklaus, M., Gerlic, M., Kurowska-Stolarska, M., Rainey, A-A., Pich, D., McInnes, I.B., Hammerschmidt, W., O'Neill, L.A.J., Masters, S.L.
miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1beta Production.
Journal of Immunology 189(8), 3795-3799. (2012).

Higgs, R., Higgins, S. C., Ross, P. J., Mills, K. H. G.
Immunity to the respiratory pathogen Bordetella pertussis.
Mucosal Immunology 5(5), 485-500.

Hollville, E., Martin, S. J.
Greasing the path BAX/BAK activation.
Cell 148(5): 845-846. (2012).

Jones, S.A., Sutton, C.E., Cua, D., Mills, K.H.
Therapeutic potential of targeting IL-17.
Nature Immunology 13(11): 1022-1025.

Klionsky, D. J. et al.
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 8(4): 445-544. Citations: 14

Lynch, M.A., Mills, K.H.
Immunology meets neuroscience-opportunities for immune intervention in neurodegenerative diseases.
Brain Behaviour and Immunity 26: 1-10. (2012). Citations: 2

Macdonald, S.H., Woodward, E., Coleman, M.M., Nadarajan, P., Chew, W.M., McLaughlin, A. M., Keane, J.
Networked T Cell Death following Macrophage Infection by Mycobacterium tuberculosis.
PLoS One 7(6): e38488 (2012)

Marshall, N.A., Galvin, K.C., Corcoran, A.M., Boon, L., Higgs, R., Mills, K.H.
Immunotherapy with PI3K Inhibitor and Toll-Like Receptor Agonist Induces IFN-gamma+IL-17+ Polyfunctional T Cells That Mediate Rejection of Murine Tumors.
Cancer Research 72: 581-591. (2012). Citations: 5

Martin, S. J., Henry, C.M., Cullen, S.P.
A perspective on mammaliam caspases as positive and negative regulators of inflammation.
Molecular Cell 46(4): 387-397. (2012). Citations: 1

Mellett M, Atzei P, Horgan A, Hams E, Floss T, Wurst W, Fallon PG, Moynagh PN.
Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia.
Nature Communications 3, 1119. (2012)

Ni Cheallaigh, C., Peral de Castro, C., Coleman, M.M., Hope, J.C., Harris, J.
Macrophages and tuberculosis. In R. Takahashi, H. Kai (Eds). Handbook of Macrophages: Life Cycle, Functions and Diseases.
New York: Nova Publishers, pp 1-41. (2012)

O'Neill, L. A. J.
"Transflammation": when innate immunity meets induced pluripotency.
Cell 151(3): 471-473. (2012).

Peral de Castro, C., Jones, S.A., Ni Cheallaigh, C., Hearnden, C.A., Williams, L., Winter, J., Lavelle, E.C., Mills, K.H.G., Harris, J.
Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion.
Journal of Immunology 189(8), 4144-4153. (2012).

Stack, J., Bowie, A.G.
Poxviral protein A46 antagonises toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions.
Journal of Biological Chemistry 287(27): 22672-22682. (2012)

Tynan. G.A., McNaughton, A., Jarnicki, A., Tsuji, T., Lavelle, E. C.
Polymixin B inadequately quenches the effects of contaminating lipopolysaccharide on murine dendritic cells.
PLoS One 7(5): e37621. (2012).

Ward, S. G., O'Neill, L. A.
Spurs in the hunt for new immunomodulatory drug targets.
Current Opinion in Pharmacology 12(4): 439-443. (2012).

Wen, H., Ting, J. P., O'Neill, L. A. J.
A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation?
Nature Immunology 13(4): 352-357. (2012). Citations: 7

 

2011

Afonina, I.S., Tynan, G.A., Logue, S.E., Cullen, S.P., Bots, M., Luthi, A.U., Reeves, E.P., McElvaney, N.G., Medema, J.P., Lavelle, E.C., Martin, S.J.
Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1alpha.
Molecular Cell 44: 265-278. (2011) Citations: 7

Brereton, C. F., Sutton, C. E., Ross, P. J., Iwakura, Y., Pizza, M., Rappuoli, R., Lavelle, E. C., and Mills, K. H.
Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production.
Journal of Immunology 186: 5896-5906. (2011) Citations: 11

Byrne, W.L., Mills, K.H., Lederer, J.A., O'Sullivan, G.C.
Targeting regulatory T cells in cancer.
Cancer Research 71: 6915-6920. (2011) Citations: 4

Cullen, S.P., Henry, C.M., Martin, S.J.
Staying alive: defensive strategies in the BCL-2 family playbook.
Molecular Cell 44(4): 509-510. (2011).

Dungan, L.S., Mills, K.H.
Caspase-1-processed IL-1 family cytokines play a vital role in driving innate IL-17.
Cytokine 56: 126-132. (2011)

Dunne, A.
Inflammasome activation: from inflammatory disease to infection.
Biochemical Society Transactions 39: 669-673. (2011) Citations: 6

Dunne, A., Marshall, N.A., Mills, K.H.
TLR based therapeutics.
Current Opinion in Pharmacology 11: 404-411. (2011) Citations: 9

Hanrahan, O., Harris, J., Egan, C.
Advanced microscopy: laser scanning confocal microscopy.
Methods in Molecular Biology 784: 169-180. (2011)

Harris, J.
Autophagy and cytokines.
Cytokine 56: 140-144. (2011) Citations: 14

Harris, J., Hartman, M., Roche, C., Zeng, S.J.G., O'Shea, A., Sharp, F.A., Lambe, E.M., Creagh, E.M., Golenbock, D.T., Tschopp, J., Kornfeld, H., Fitzgerald, K.A., Lavelle, E.C.
Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
Journal of Biological Chemistry 286: 9587-9597. (2011) Citations: 37

Jefferies, C., Wynne, C., Higgs, R.
Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease?
Nature Reviews Immunology 11: 617-625. (2011) Citations: 6

Keating, S.E., Baran, M., Bowie, A.G.
Cytosolic DNA sensors regulating type I interferon induction.
Trends in Immunology 32: 574-581. (2011). Citations: 14

Lavelle, E.C., McNaughton, A., McNeela, E.
NLRP3 in protective immunity and vaccination against respiratory infection.
Expert Review of Vaccines 10: 255-257. (2011)

Masters, S.L., Latz, E., O'Neill, L.A.
The inflammasome in atherosclerosis and type 2 diabetes.
Science Translational Medicine 3: 81ps17. (2011) Citations: 9

Masters, S.L., O'Neill, L.A.
Disease-associated amyloid and misfolded protein aggregates activate the inflammasome.
Trends in Molecular Medicine 17: 276-282. (2011) Citations: 7

McLoughlin, R.M., Mills, K.H.
Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma.
Journal of Allergy and Clinical Immunology 127: 1097-1107; quiz 1108-1099. (2011) Citations: 24

Mellett, M., Atzei, P., Jackson, R., O'Neill, L.A., Moynagh, P.N.
Mal mediates TLR-induced activation of CREB and expression of IL-10.
Journal of Immunology 186: 4925-4935. (2011) Citations: 10

Ni Cheallaigh, C., Keane, J., Lavelle, E.C., Hope, J.C., Harris, J.
Autophagy in the immune response to tuberculosis: clinical perspectives.
Clinical and Experimental Immunology 164: 291-300. (2011) Citations: 8

O'Neill, L.A.
Plant science. Innate immunity in plants goes to the PUB.
Science 332: 1386-1387. (2011)

O'Neill, L.A.
Retrospective. Jurg Tschopp (1951-2011).
Science 332: 679. (2011)

O'Neill, L.A., Bowie, A.G.
The powerstroke and camshaft of the RIG-I antiviral RNA detection machine.
Cell 147: 259-261. (2011) Citations: 2

O'Neill, L.A., Sheedy, F.J., McCoy, C.E.
MicroRNAs: the fine-tuners of Toll-like receptor signalling.
Nature Reviews Immunology 11: 163-175. (2011) Citations: 74

Ryan, A., Lynch, M., Smith, S.M., Amu, S., Nel, H.J., McCoy, C.E., Dowling, J.K., Draper, E., O'Reilly, V., McCarthy, C., O'Brien, J., Ni Eidhin, D., O'Connell, M.J., Keogh, B., Morton, C.O., Rogers, T.R., Fallon, P.G., O'Neill, L.A., Kelleher, D., Loscher, C.E.
A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.
PLoS Pathogens 7: e1002076. (2011) Citations: 11

Ryan, R.C., O'Sullivan, M.P., Keane, J.
Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells.
BMC Microbiology 11: 237. (2011) Citations: 2

Schijns, V.E., Lavelle, E.C.
Trends in vaccine adjuvants.
Expert Review of Vaccines 10: 539-550. (2011) Citations: 15

Smith, S.M., Moran, A.P., Duggan, S.P., Ahmed, S.E., Mohamed, A.S., Windle, H.J., O'Neill, L.A., Kelleher, D.P.
Tribbles 3: a novel regulator of TLR2-mediated signaling in response to Helicobacter pylori lipopolysaccharide.
Journal of Immunology 186: 2462-2471. (2011) Citations: 10

 

2010

Coleman, M.M., Keane, J., and Mills, K.H.
Editorial: Tregs and BCG--dangerous liaisons in TB.
Journal of Leukocyte Biology 88, 1067-1069. (2010)

Cullen, S.P., Brunet, M., and Martin, S.J.
Granzymes in cancer and immunity.
Cell Death and Differentiation 17, 616-623. (2010) Citations: 32

Dinarello, C. et al.
IL-1 family nomenclature.
Nature Immunology 11(11): 973. Citations: 33

Dunne, A., Ross, P.J., Pospisilova, E., Masin, J., Meaney, A., Sutton, C.E., Iwakura, Y., Tschopp, J., Sebo, P., Mills, K.H.
Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis.
Journal of Immunology 185: 1711-1719. (2010) Citations: 34

Harris, J., Keane, J.
How tumour necrosis factor blockers interfere with tuberculosis immunity.
Clinical and Experimental Immunology 161: 1-9. (2010) Citations: 38

Harris, J., Sharp, F.A., Lavelle, E.C.
The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants.
European Journal of Immunology 40: 634-638. (2010) Citations: 10

Lysakova-Devine, T., Keogh, B., Harrington, B., Nagpal, K., Halle, A., Golenbock, D.T., Monie, T., Bowie, A.G.
Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.
Journal of Immunology 185: 4261-4271. (2010) Citations: 12

Masters, S.L., Dunne, A., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., Mullooly, N., Mielke, L.A., Harris, J., Coll, R.C., Mills, K.H., Mok, K.H., Newsholme, P., Nunez, G., Yodoi, J., Kahn, S.E., Lavelle, E.C., O'Neill, L.A.
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes.
Nature Immunology 11: 897-904. (2010) Citations: 114

Masters, S.L., Mielke, L.A., Cornish, A.L., Sutton, C.E., O'Donnell, J., Cengia, L.H., Roberts, A.W., Wicks, I.P., Mills, K.H., Croker, B.A.
Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production.
EMBO Reports 11: 640-646. (2010) Citations: 13

Masters, S.L., Walsh, P.T.
Release of the mitochondrial endosymbiont helps explain sterile inflammation.
Proceedings of the National Acadamy of Sciences of the USA 107: E32. (2010)

O'Neill, L.A.
Outfoxing Foxo1 with miR-182.
Nature Immunology 11: 983-984. (2010) Citations: 1

O'Neill, L.A.J., Bowie, A.G.
Sensing and signalling in antiviral immunity.
Current Biology 7(13): R328-R333. Citations: 47

 

2009

Harris, J., Hanrahan, O., De Haro, S.A.
Measuring autophagy in macrophages.
Currents Protocols in Immunology Chapter 14: Unit 14 14. (2009) Citations: 3

Harris, J., Hope, J.C., Lavelle, E.C.
Autophagy and the immune response to TB.
Transboundary and Emerging Diseases 56: 248-254. Citations: 11

Mills, K.H.
Designer adjuvants for enhancing the efficacy of infectious disease and cancer vaccines based on suppression of regulatory T cell induction.
Immunology Letters 122(2): 108-111 (2009) Citations: 14

Mills, K.H., Dunne, A.
Immune modulation: IL-1, master mediator or initiator of inflammation.
Nature Medicine 15: 1363-1364. (2009) Citations: 17