Animal experiment due consideration
Proceedings of the XVIIth COMS round table conference, Geneva, Switzerland, 8th and 9th December, 1983 edited by Z. Bankowski and N. Howard-Jones,
The advancement of biological knowledge and the development of improved means for the protection of health and well-being both of humans and of animals require recourse to experimentation on intact live animals of a wide variety of species.
Methods such as mathematics models, computer simulation and in vitro biological systems should be used wherever appropriate.
Animal experiments should be undertaken only after due consideration of their relevance for human or animal health and the advancement of biological knowledge.
The animals selected for an experiment should be of an appropriate species and quality, and the minimum number required, to obtain scientifically valid results.
Investigators and other personnel should never fail to treat animals as sentient, and should regard their proper care and use and the avoidance of minimisation of discomfort, distress, or pain as ethical imperatives.
Investigators should assume that procedures that would cause pain in human beings cause pain in other vertebrate species although more needs to be known about the perception of pain in animals.
Procedures with animals that may cause more than momentary or minimal pain or distress should be performed with appropriate sedation, analgesia or anaesthesia in accordance with accepted veterinary practice. Surgical or other painful procedures should not be performed on unanaesthetised animals paralysed by chemical agents. Where wavers are required in relation to the provisions of article VII, the decisions should not rest solely with the investigators directly concerned but should be made, with due regard to the provisions of articles IV, V and VI, by a suitably constituted review body. Such wavers should not be made solely for the purpose of teaching or demonstration.
At the end of, or when appropriate during an experiment, animals that would otherwise suffer severe or chronic pain, distress, discomfort, or disablement that cannot be relieved should be painlessly killed.
The best possible living conditions should be maintained for animals kept for biomedical purposes. Normally the care of animals should be under the supervision of veterinarians having experience in laboratory animal science. In any case, veterinary care should be available as required.
It is the responsibility of the director on an institute or department using animals to ensure that investigators and personnel have appropriate qualifications or experience for conducting procedures on animals. Adequate opportunities shall be provided for in-service training, including the proper and humane concern for the animals under their care.
In addition the college is committed to implement the principles of Reduction, Refinement and Replacement in its work involving animals. It will actively encourage researchers to use alternative methods of biological research involving procedures which can completely replace the need for animals experiments reduce the number of animals required, or diminish the amount of pain or distress suffered by animals in meeting the essential needs of humans and animals.